Extract of okra lowers blood glucose and serum lipids in high-fat diet-induced obese C57BL/6 mice
文献类型：期刊论文
| 作者 | Fan, Shengjie2; Zhang, Yu2; Sun, Qinhu1; Yu, Lijing2; Li, Mingxia2; Zheng, Bin2; Wu, Ximin2; Yang, Baican2; Li, Yiming2; Huang, Cheng2 |
| 刊名 | The Journal of nutritional biochemistry
 |
| 出版日期 | 2014-07 |
| 卷号 | 25期号:7页码:702-9 |
| ISSN号 | 1873-4847 |
| DOI | 10.1016/j.jnutbio.2014.02.010 |
| 文献子类 | Article |
| 英文摘要 | Okra is an important tropical vegetable and source of dietary medicine. Here, we assayed the effects of an ethanol extract of okra (EO) and its major flavonoids isoquercitrin and quercetin 3-O-gentiobioside on metabolic disorders in high-fat diet-induced obese mouse. We found that treatment with EO, isoquercitrin and quercetin 3-O-gentiobioside reduced blood glucose and serum insulin levels and improved glucose tolerance in obese mice. Meanwhile, serum triglyceride levels and liver morphology in the mice were significantly ameliorated by EO and isoquercitrin treatment. Total cholesterol levels in isoquercitrin and quercetin 3-O-gentiobioside treated mice were also reduced. We also found that EO inhibited the expression of nuclear receptor transcription factor PPARγ, which is an important regulator of lipid and glucose homeostasis. Furthermore, we determined that EO and quercetin 3-O-gentiobioside have antioxidant activity in vitro. Our results indicate that okra may serve as a dietary therapy for hyperglycemia and hypertriglyceridemia. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266387]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Huang, Cheng |
| 作者单位 | 1.Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China 2.School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; |
| 推荐引用方式 GB/T 7714 | Fan, Shengjie,Zhang, Yu,Sun, Qinhu,et al. Extract of okra lowers blood glucose and serum lipids in high-fat diet-induced obese C57BL/6 mice[J]. The Journal of nutritional biochemistry,2014,25(7):702-9. |
| APA | Fan, Shengjie.,Zhang, Yu.,Sun, Qinhu.,Yu, Lijing.,Li, Mingxia.,...&Huang, Cheng.(2014).Extract of okra lowers blood glucose and serum lipids in high-fat diet-induced obese C57BL/6 mice.The Journal of nutritional biochemistry,25(7),702-9. |
| MLA | Fan, Shengjie,et al."Extract of okra lowers blood glucose and serum lipids in high-fat diet-induced obese C57BL/6 mice".The Journal of nutritional biochemistry 25.7(2014):702-9. |
入库方式： OAI收割
来源：上海药物研究所
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