Astragaloside IV improves lipid metabolism in obese mice by alleviation of leptin resistance and regulation of thermogenic network
文献类型：期刊论文
| 作者 | Wu, Hui; Gao, Yan; Shi, Hai-Lian; Qin, Li-Yue; Huang, Fei; Lan, Yun-Yi; Zhang, Bei-Bei; Hu, Zhi-Bi; Wu, Xiao-Jun |
| 刊名 | Scientific reports
 |
| 出版日期 | 2016-07-22 |
| 卷号 | 6页码:30190 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep30190 |
| 文献子类 | Article |
| 英文摘要 | Obesity is a worldwide threat to public health in modern society, which may result from leptin resistance and disorder of thermogenesis. The present study investigated whether astragaloside IV (ASI) could prevent obesity in high-fat diet (HFD)-fed and db/db mice. In HFD-fed mice, ASI prevented body weight gain, lowered serum triglyceride and total cholesterol levels, mitigated liver lipid accumulation, reduced fat tissues and decreased the enlargement of adipose cells. In metabolic chambers, ASI lessened appetite of the mice, decreased their respiratory exchange ratio and elevated VCO2 and VO2 without altering circadian motor activity. Moreover, ASI modulated thermogenesis associated gene expressions in liver and brawn fat tissues, as well as leptin resistance evidenced by altered expressions of leptin, leptin receptor (ObR) or appetite associated genes. In SH-SY5Y cells, ASI enhanced leptin signaling transduction. However, in db/db mice, ASI did not change body weight gain and appetite associated genes. But it decreased serum triglyceride and total cholesterol levels as well as liver triglyceride. Meanwhile, it significantly modulated gene expressions of PPARα, PGC1-α, UCP2, ACC, SCD1, LPL, AP2, CD36 and SREBP-1c. Collectively, our study suggested that ASI could efficiently improve lipid metabolism in obese mice probably through enhancing leptin sensitivity and modulating thermogenic network. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266401]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | Shanghai Key Laboratory of Complex Prescription, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China |
| 推荐引用方式 GB/T 7714 | Wu, Hui,Gao, Yan,Shi, Hai-Lian,et al. Astragaloside IV improves lipid metabolism in obese mice by alleviation of leptin resistance and regulation of thermogenic network[J]. Scientific reports,2016,6:30190. |
| APA | Wu, Hui.,Gao, Yan.,Shi, Hai-Lian.,Qin, Li-Yue.,Huang, Fei.,...&Wu, Xiao-Jun.(2016).Astragaloside IV improves lipid metabolism in obese mice by alleviation of leptin resistance and regulation of thermogenic network.Scientific reports,6,30190. |
| MLA | Wu, Hui,et al."Astragaloside IV improves lipid metabolism in obese mice by alleviation of leptin resistance and regulation of thermogenic network".Scientific reports 6(2016):30190. |
入库方式： OAI收割
来源：上海药物研究所
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