Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation
文献类型：期刊论文
| 作者 | Yang, Fan; Tang, Xiaowen; Ding, Lili; Zhou, Yue; Yang, Qiaoling; Gong, Junting; Wang, Guangyun; Wang, Zhengtao; Yang, Li |
| 刊名 | Scientific reports
 |
| 出版日期 | 2016-09-14 |
| 卷号 | 6页码:33052 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep33052 |
| 文献子类 | Article |
| 英文摘要 | Cholestasis is a clinically significant symptom and widely associated with liver diseases, however, there are very few effective therapies for cholestasis. Danning tablet (DNT, a Chinese patent medicine preparation) has been clinically used to treat human liver and gallbladder diseases for more than 20 years in China. However, which ingredients of DNT contributed to this beneficial effect and their mechanistic underpinnings have been largely unknown. In the present study, we discovered that DNT not only demonstrated greater benefits for cholecystitis patients after cholecystectomy surgery in clinic but also showed protective effect against alpha-naphthylisothiocyanate (ANIT)-induced cholestasis model in rodent. Curcumin, one major compound derived from DNT, exerted the protective effect against cholestasis through farnesoid X receptor (FXR), which has been focused as potential therapeutic targets for treating cholestasis. The underlying mechanism of curcumin against cholestasis was restoring bile acid homeostasis and antagonizing inflammatory responses in a FXR-dependent manner and in turn contributed to overall cholestasis attenuation. Collectively, curcumin can be served as a potential treatment option for liver injury with cholestasis. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266404]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | The MOE Key Laboratory for Standardization of Chinese Medicines and the Shanghai Key Laboratory of Compound Chinese Medicines Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
| 推荐引用方式 GB/T 7714 | Yang, Fan,Tang, Xiaowen,Ding, Lili,et al. Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation[J]. Scientific reports,2016,6:33052. |
| APA | Yang, Fan.,Tang, Xiaowen.,Ding, Lili.,Zhou, Yue.,Yang, Qiaoling.,...&Yang, Li.(2016).Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation.Scientific reports,6,33052. |
| MLA | Yang, Fan,et al."Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation".Scientific reports 6(2016):33052. |
入库方式： OAI收割
来源：上海药物研究所
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