A novel semi-synthetic andrographolide analogue A5 inhibits tumor angiogenesis via blocking the VEGFR2-p38/ERK1/2 signal pathway
文献类型：期刊论文
| 作者 | Gong, Chenyuan; Xu, Chong; Ji, Lili; Wang, Zhengtao |
| 刊名 | Bioscience trends
 |
| 出版日期 | 2013-10 |
| 卷号 | 7期号:5页码:230-6 |
| ISSN号 | 1881-7823 |
| 文献子类 | Article |
| 英文摘要 | The present study is designed to observe the inhibitory effect of compound A5, a semi-synthetic analogue of the natural compound andrographolide, on angiogenesis and its underlying mechanism. Compound A5 is semi-synthesized from natural compound neoandrographolide. Andrographolide, the aglycon of neoandrograoholide, and A5 all inhibited vascular endothelial growth factor (VEGF)-induced human umbilical vein endothelial cells (HUVECs) proliferation, and that the inhibition shown by A5 is the best. A5 also inhibited VEGF-induced tube formation in HUVECs in a concentration-dependent manner. VEGF-induced neoangiogenesis in vivo was observed by Matrigel formation assay. The Matrigel picture and CD31 staining results showed that A5 inhibited VEGF-induced neoangiogenesis in vivo. Further, Western-blot results showed that A5 inhibited VEGF-induced phosphorylation of VEGF receptor 2 (VEGFR2), extracellular signal-regulated kinase 1 and 2 (ERK1/2), and p38 kinase. The antitumor effect of A5 was analyzed in a xenograft mouse tumor model inoculated with hepatoma Hep3B cells. The results showed that A5 decreased tumor weight and tumor size without affecting body weight in the xenograft mouse, and A5 also decreased CD31 staining in tumor tissue. Taken together, the present study demonstrates that compound A5 inhibits tumor growth via blocking neoangiogenesis, and the cellular VEGFR2-p38/ERK1/2 signal pathway. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266408]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | The MOE Key Laboratory for Standardization of Chinese Medicines and The Shanghai Key Laboratory for Compound Chinese medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China |
| 推荐引用方式 GB/T 7714 | Gong, Chenyuan,Xu, Chong,Ji, Lili,et al. A novel semi-synthetic andrographolide analogue A5 inhibits tumor angiogenesis via blocking the VEGFR2-p38/ERK1/2 signal pathway[J]. Bioscience trends,2013,7(5):230-6. |
| APA | Gong, Chenyuan,Xu, Chong,Ji, Lili,&Wang, Zhengtao.(2013).A novel semi-synthetic andrographolide analogue A5 inhibits tumor angiogenesis via blocking the VEGFR2-p38/ERK1/2 signal pathway.Bioscience trends,7(5),230-6. |
| MLA | Gong, Chenyuan,et al."A novel semi-synthetic andrographolide analogue A5 inhibits tumor angiogenesis via blocking the VEGFR2-p38/ERK1/2 signal pathway".Bioscience trends 7.5(2013):230-6. |
入库方式： OAI收割
来源：上海药物研究所
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