Harmine is an inflammatory inhibitor through the suppression of NF-κB signaling
文献类型：期刊论文
| 作者 | Liu, Xin3; Li, Mingxia3; Tan, Si3; Wang, Changhong1,2; Fan, Shengjie3; Huang, Cheng3 |
| 刊名 | Biochemical and biophysical research communications
 |
| 出版日期 | 2017-07-29 |
| 卷号 | 489期号:3页码:332-338 |
| ISSN号 | 1090-2104 |
| DOI | 10.1016/j.bbrc.2017.05.126 |
| 文献子类 | Article |
| 英文摘要 | Harmine is a major constituent in a hallucinogenic botanical mixture ayahuasca and medical plant Peganum harmala L. The plant is used for various illnesses and exhibits anti-inflammatory activity. However, the active constituents remain unclear. Here, we screened the seven alkaloids in P. harmala for their anti-inflammatory activity using an nuclear factor-κB (NF-κB) reporter assay. We found that harmine and harmol could inhibit NF-κB transactivity. As the most abundant compound, harmine inhibited tumor necrosis factor-α (TNF-α)- and lipopolysaccharides (LPS)-induced NF-κB transactivity and nuclear translocation in mouse macrophage RAW 264.7 cells. The mRNA and protein levels of NF-κB downstream inflammatory cytokines also reduced. In an LPS-challenged mouse model, harmine markedly averted inflammatory damage of the lung, and decreased serum TNF-α, interleukin-1β (IL-1β) and IL-6 levels. Our data indicate that harmine may exert the anti-inflammatory effect by inhibition of the NF-κB signaling pathway and harmine is probably responsible for the anti-inflammatory effects of P. harmala. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266422]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Fan, Shengjie; Huang, Cheng |
| 作者单位 | 1.Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201210, China 2.Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; 3.Drug Discovery Lab, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; |
| 推荐引用方式 GB/T 7714 | Liu, Xin,Li, Mingxia,Tan, Si,et al. Harmine is an inflammatory inhibitor through the suppression of NF-κB signaling[J]. Biochemical and biophysical research communications,2017,489(3):332-338. |
| APA | Liu, Xin,Li, Mingxia,Tan, Si,Wang, Changhong,Fan, Shengjie,&Huang, Cheng.(2017).Harmine is an inflammatory inhibitor through the suppression of NF-κB signaling.Biochemical and biophysical research communications,489(3),332-338. |
| MLA | Liu, Xin,et al."Harmine is an inflammatory inhibitor through the suppression of NF-κB signaling".Biochemical and biophysical research communications 489.3(2017):332-338. |
入库方式： OAI收割
来源：上海药物研究所
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