Chemical constituents from hypoglycemic active part of Plantaginis Semen
文献类型：期刊论文
| 作者 | Peng, Qing-Hua; Han, Zhu-Zhen; Tong, Ren-Chao; Hu, Xin-Quan; Yang, Qi-Ming; Qi, Meng; Shi, Yan-Hong ; Wang, Zheng-Tao; Yang, Li
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| 刊名 | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
 |
| 出版日期 | 2017-11 |
| 卷号 | 42期号:21页码:4150-4153 |
| ISSN号 | 1001-5302 |
| DOI | 10.19540/j.cnki.cjcmm.20170905.009 |
| 文献子类 | Meeting Abstract;Article |
| 英文摘要 | The chemical constituents of Plantaginis Semen with hypoglycemic effect was investigated in this paper. The previous results of the in vivo hypoglycemic effect showed that 60% ethanol extract of Plantaginis Semen decreased the levels of FBG and improved the glucose tolerance in high fat diet(HFD)-induced diabetic C57BL/6 mice. Then, in the present study, the above potential bioactive extract was separated and purified by silica gel, ODS, Sephadex LH-20 column chromatography, medium pressure liquid chromatography(MPLC)and preparative HPLC. The structures of isolated compounds were identified by physicochemical properties and spectral analyses. Eight compounds were obtained and identified as 4, 4a, 5, 7a-tetrahydro-7-(hydroxymethyl)cyclopenta[c]pyran-3(1H)-one(1), iridolactone(2), pedicularislacton(3), rehmaglutin C(4), geniposidic acid(5), p-hydroxylphenylglycerol(6), 1, 2-benzenediol-4-(2-hydroxyethyl)(7), and 3-buten-2-one-4-[3-(β-D-glucopyranosyloxy)-4-hydroxyphenyl](8). Among them, compounds 1-5 were iridoids, and 6-8 were phenolic acids. Compound 1 was a new natural product, and compounds 2-4, 6 and 8 were isolated from the Plantaginaceae family for the first time. |
| 语种 | 中文 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266425]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | The Key Laboratory of Standardization of Chinese Medicines, Ministry of Education, Institute of Chinese Materia Medica of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
| 推荐引用方式 GB/T 7714 | Peng, Qing-Hua,Han, Zhu-Zhen,Tong, Ren-Chao,et al. Chemical constituents from hypoglycemic active part of Plantaginis Semen[J]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,2017,42(21):4150-4153. |
| APA | Peng, Qing-Hua.,Han, Zhu-Zhen.,Tong, Ren-Chao.,Hu, Xin-Quan.,Yang, Qi-Ming.,...&Yang, Li.(2017).Chemical constituents from hypoglycemic active part of Plantaginis Semen.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,42(21),4150-4153. |
| MLA | Peng, Qing-Hua,et al."Chemical constituents from hypoglycemic active part of Plantaginis Semen".Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 42.21(2017):4150-4153. |
入库方式： OAI收割
来源：上海药物研究所
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