Sulfated beta-glucan derived from oat bran with potent anti-HIV activity
文献类型：期刊论文
| 作者 | Wang, Shun Chun; Bligh, S W Annie; Zhu, Chang Lian; Shi, Song Shan; Wang, Zheng Tao; Hu, Zhi Bi; Crowder, John; Branford-White, Christopher; Vella, Cherelyn |
| 刊名 | Journal of agricultural and food chemistry
 |
| 出版日期 | 2008-04-23 |
| 卷号 | 56期号:8页码:2624-9 |
| ISSN号 | 0021-8561 |
| DOI | 10.1021/jf072888h |
| 文献子类 | Article |
| 英文摘要 | China is a major producer of oats; the annual harvested area of 350,000 ha yields approximately 465,000 tons, giving an average yield of 1.33 tons/ha. The bran is not used for animal feed as it is of poor digestibility and low nutritive content and is considered a waste byproduct. Therefore, it is advantageous to produce a value-added product from the bran. We extracted the native polysaccharide, a linear (1-3)-, (1-4)-linked beta-glucan (OBG) from the oat bran and synthesized a sulfated derivative OBGS containing 36.5% sulfate. OBGS had potent activity against a primary isolate of human immunodeficiency virus (HIV-1) in peripheral blood mononuclear cells at a concentration (EC(50)=5.98 x 10(-4) microM) approximately 15,000 times below its cytotoxic concentration. OBGS was also active postinfection (EC(50)=5.3 x 10(-4) microM) and protected pretreated peripheral mononuclear cells (EC(50)=5.2 x 10(-2) microM) washed free of the compounds prior to infection. Thus, OBGS has potential as a vaginal microbicide and is the first such report for oat bran derived sulfated beta-glucan. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266430]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cai Lun Road, Zhangjiang Hi-Tech Park, Shanghai 201210, People's Republic of China |
| 推荐引用方式 GB/T 7714 | Wang, Shun Chun,Bligh, S W Annie,Zhu, Chang Lian,et al. Sulfated beta-glucan derived from oat bran with potent anti-HIV activity[J]. Journal of agricultural and food chemistry,2008,56(8):2624-9. |
| APA | Wang, Shun Chun.,Bligh, S W Annie.,Zhu, Chang Lian.,Shi, Song Shan.,Wang, Zheng Tao.,...&Vella, Cherelyn.(2008).Sulfated beta-glucan derived from oat bran with potent anti-HIV activity.Journal of agricultural and food chemistry,56(8),2624-9. |
| MLA | Wang, Shun Chun,et al."Sulfated beta-glucan derived from oat bran with potent anti-HIV activity".Journal of agricultural and food chemistry 56.8(2008):2624-9. |
入库方式： OAI收割
来源：上海药物研究所
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