A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration
文献类型：期刊论文
| 作者 | Duan, Jingze1; Dang, Yang1; Meng, Houjun1; Wang, Huizhen1; Ma, Ping2; Li, Guowen3; Wu, Tao3; Xie, Yan1 |
| 刊名 | European journal of drug metabolism and pharmacokinetics
 |
| 出版日期 | 2016-06 |
| 卷号 | 41期号:3页码:239-49 |
| ISSN号 | 2107-0180 |
| DOI | 10.1007/s13318-015-0254-9 |
| 文献子类 | Article |
| 英文摘要 | Pharmacokinetic properties of isorhamnetin, quercetin, and kaempferol in three different total flavones of Hippophae rhamnoides (TFH) preparations were compared after oral administration to beagle dogs by a UPLC-MS method. The pharmacokinetic results showed that C max of isorhamnetin and quercetin in TFH solid dispersion (TFH-SD) and TFH self-emulsifying (TFH-SE) preparations was significantly enhanced than that in TFH preparations (p < 0.05). The AUCs of isorhamnetin and quercetin in TFH-SD were 5.9- and 3.1-fold higher than that of TFH, while the AUCs of isorhamnetin and quercetin in TFH-SE were 3.4- and 2.4-fold higher than that of TFH. These findings suggested that the oral bioavailability of isorhamnetin and quercetin in beagle dogs can be significantly increased in TFH-SD and TFH-SE preparations compared to TFH preparations, which was helpful to explore the new forms for oral administration TFH and explain their in vivo processes. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266431]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xie, Yan |
| 作者单位 | 1.Research Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, People's Republic of China; 2.Global Pharmaceutical Research and Development, Hospira Inc., 1776 North Centennial Drive, Mcpherson, KS, 67460, USA; 3.Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China |
| 推荐引用方式 GB/T 7714 | Duan, Jingze,Dang, Yang,Meng, Houjun,et al. A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration[J]. European journal of drug metabolism and pharmacokinetics,2016,41(3):239-49. |
| APA | Duan, Jingze.,Dang, Yang.,Meng, Houjun.,Wang, Huizhen.,Ma, Ping.,...&Xie, Yan.(2016).A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration.European journal of drug metabolism and pharmacokinetics,41(3),239-49. |
| MLA | Duan, Jingze,et al."A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration".European journal of drug metabolism and pharmacokinetics 41.3(2016):239-49. |
入库方式： OAI收割
来源：上海药物研究所
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