A novel multi-target regression framework for time-series prediction of drug efficacy
文献类型：期刊论文
| 作者 | Li, Haiqing2; Zhang, Wei2; Chen, Ying1; Guo, Yumeng2; Li, Guo-Zheng2; Zhu, Xiaoxin1 |
| 刊名 | Scientific reports
 |
| 出版日期 | 2017-01-18 |
| 卷号 | 7页码:40652 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep40652 |
| 文献子类 | Article |
| 英文摘要 | Excavating from small samples is a challenging pharmacokinetic problem, where statistical methods can be applied. Pharmacokinetic data is special due to the small samples of high dimensionality, which makes it difficult to adopt conventional methods to predict the efficacy of traditional Chinese medicine (TCM) prescription. The main purpose of our study is to obtain some knowledge of the correlation in TCM prescription. Here, a novel method named Multi-target Regression Framework to deal with the problem of efficacy prediction is proposed. We employ the correlation between the values of different time sequences and add predictive targets of previous time as features to predict the value of current time. Several experiments are conducted to test the validity of our method and the results of leave-one-out cross-validation clearly manifest the competitiveness of our framework. Compared with linear regression, artificial neural networks, and partial least squares, support vector regression combined with our framework demonstrates the best performance, and appears to be more suitable for this task. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266438]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing, 100700, China 2.Department of Control Science and Engineering, Tongji University, Shanghai, 201804, China; |
| 推荐引用方式 GB/T 7714 | Li, Haiqing,Zhang, Wei,Chen, Ying,et al. A novel multi-target regression framework for time-series prediction of drug efficacy[J]. Scientific reports,2017,7:40652. |
| APA | Li, Haiqing,Zhang, Wei,Chen, Ying,Guo, Yumeng,Li, Guo-Zheng,&Zhu, Xiaoxin.(2017).A novel multi-target regression framework for time-series prediction of drug efficacy.Scientific reports,7,40652. |
| MLA | Li, Haiqing,et al."A novel multi-target regression framework for time-series prediction of drug efficacy".Scientific reports 7(2017):40652. |
入库方式： OAI收割
来源：上海药物研究所
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