Bile acid signaling and bariatric surgery
文献类型：期刊论文
| 作者 | Tian, Jingyan1; Huang, Silvia2; Sun, Siming3; Ding, Lili3; Zhang, Eryun3; Huang, Wendong3 |
| 刊名 | Liver research
 |
| 出版日期 | 2017-12 |
| 卷号 | 1期号:4页码:208-213 |
| ISSN号 | 2096-2878 |
| DOI | 10.1016/j.livres.2017.12.007 |
| 文献子类 | Article |
| 英文摘要 | The rapid worldwide rise in obesity rates over the past few decades imposes an urgent need to develop effective strategies for treating obesity and associated metabolic complications. Bariatric surgical procedures, such as Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG), currently provide the most effective treatment for obesity and type 2 diabetes (T2D), as well as for non-alcoholic steatohepatitis (NASH). However, the underlying mechanisms of the beneficial effects of bariatric surgery remain elusive. Recent studies have identified bile acids as potential signaling molecules involved in the beneficial effects of bariatric surgery. This review focuses on the most recent studies on the roles of bile acids and bile acid receptors Farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 5 (TGR5) in bariatric surgery. We also discuss the possibility of modulating bile acid signaling as a pharmacological therapeutic approach to treating obesity and its associated metabolic complications. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266444]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.National Clinical Research Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; 2.Eugene Robert Summer Program, City of Hope, Duarte, CA, USA; 3.Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA, USA |
| 推荐引用方式 GB/T 7714 | Tian, Jingyan,Huang, Silvia,Sun, Siming,et al. Bile acid signaling and bariatric surgery[J]. Liver research,2017,1(4):208-213. |
| APA | Tian, Jingyan,Huang, Silvia,Sun, Siming,Ding, Lili,Zhang, Eryun,&Huang, Wendong.(2017).Bile acid signaling and bariatric surgery.Liver research,1(4),208-213. |
| MLA | Tian, Jingyan,et al."Bile acid signaling and bariatric surgery".Liver research 1.4(2017):208-213. |
入库方式： OAI收割
来源：上海药物研究所
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