Embedding fluorescent mesoporous silica nanoparticles into biocompatible nanogels for tumor cell imaging and thermo/pH-sensitive in vitro drug release
文献类型：期刊论文
| 作者 | Gui, Rijun1,2; Wang, Yanfeng1; Sun, Jie1 |
| 刊名 | Colloids and surfaces. B, Biointerfaces
 |
| 出版日期 | 2014-04-01 |
| 卷号 | 116页码:518-25 |
| ISSN号 | 1873-4367 |
| DOI | 10.1016/j.colsurfb.2014.01.044 |
| 文献子类 | Article |
| 英文摘要 | Thermo/pH-sensitive/fluorescent/biocompatible nanospheres consisting of quantum dots-embedded mesoporous silica nanoparticles (Q-MS) as a core and poly(N-isopropylacrylamide (NIPAM))-graft-chitosan (CS) nanogels as a shell (PNIPAM-g-CS) were prepared via temperature-regulated one-pot copolymerization of NIPAM monomer and CS in the presence of Q-MS. The prepared nanospheres exhibited remarkable fluorescence/thermo/pH-sensitivity. HepG2 cells treated with nanospheres displayed bright fluorescence imaging. Loading efficiency and capacity of Doxorubicin (Dox) into nanospheres were regularly increased with the increment of Dox concentration. At a high temperature and a low pH, cumulative in vitro release of Dox from Dox-loaded nanospheres was much great and fast. Released Dox still retained high anticancer activity, and blank nanosphere carriers produced neglectful toxicity to HepG2 cells. The multifunctional nanospheres could be further developed toward temperature/pH-regulated drug carriers for in vivo tumor therapy with a rapid drug release and fluorescence imaging in targeted tissues. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266490]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Sun, Jie |
| 作者单位 | 1.Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, PR China; 2.Department of Chemistry, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China |
| 推荐引用方式 GB/T 7714 | Gui, Rijun,Wang, Yanfeng,Sun, Jie. Embedding fluorescent mesoporous silica nanoparticles into biocompatible nanogels for tumor cell imaging and thermo/pH-sensitive in vitro drug release[J]. Colloids and surfaces. B, Biointerfaces,2014,116:518-25. |
| APA | Gui, Rijun,Wang, Yanfeng,&Sun, Jie.(2014).Embedding fluorescent mesoporous silica nanoparticles into biocompatible nanogels for tumor cell imaging and thermo/pH-sensitive in vitro drug release.Colloids and surfaces. B, Biointerfaces,116,518-25. |
| MLA | Gui, Rijun,et al."Embedding fluorescent mesoporous silica nanoparticles into biocompatible nanogels for tumor cell imaging and thermo/pH-sensitive in vitro drug release".Colloids and surfaces. B, Biointerfaces 116(2014):518-25. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。