中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Chlorogenic acid suppresses monocrotaline-induced sinusoidal obstruction syndrome: The potential contribution of NFκB, Egr1, Nrf2, MAPKs and PI3K signals

文献类型:期刊论文

作者Zheng, Zhiyong1; Shi, Liang1; Sheng, Yuchen2; Zhang, Jiaqi1; Lu, Bin1; Ji, Lili1
刊名Environmental toxicology and pharmacology
出版日期2016-09
卷号46页码:80-89
ISSN号1872-7077
DOI10.1016/j.etap.2016.07.002
文献子类Article
英文摘要Hepatic sinusoidal obstruction syndrome (SOS) is a highly lethal liver disease. This study aims to observe the protection and its engaged mechanism of chlorogenic acid (CGA) against monocrotaline (MCT)-induced SOS. Results of detecting liver ascites, measuring serum transaminases, liver histological evaluation and scanning electron microscope observation all demonstrated that CGA prevented MCT-induced SOS in rats. CGA reduced MCT-induced increased liver myeloperoxidase (MPO) activity, tumor necrosis factor (TNF)α and interleukin (IL)-1β mRNA expression, toll-like receptor (TLR)-2,3,6,9 expression, and nuclear factor κB (NFκB) transcriptional activation. CGA also decreased MCT-induced early growth response1 (Egr1) activation. CGA reduced MCT-induced elevated liver malondialdehyde (MDA) amount and enhanced nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2). CGA blocked MCT-induced PI3K and MAPKs activation. In conclusion, this study demonstrates the protection of CGA against MCT-induced SOS. Transcriptional factor NFκB, Egr1 and Nrf2-regulated inflammation, coagulation-fibrinolysis, and antioxidant, and PI3K and MAPKs all contribute to such protection.
语种英语
源URL[http://119.78.100.183/handle/2S10ELR8/266497]  
专题中国科学院上海药物研究所
通讯作者Ji, Lili
作者单位1.Shanghai Key Laboratory of Complex Prescription, MOE Key Laboratory for Standardization of Chinese Medicines, SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China;
2.Center for Drug Safety Evaluation and Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China
推荐引用方式
GB/T 7714
Zheng, Zhiyong,Shi, Liang,Sheng, Yuchen,et al. Chlorogenic acid suppresses monocrotaline-induced sinusoidal obstruction syndrome: The potential contribution of NFκB, Egr1, Nrf2, MAPKs and PI3K signals[J]. Environmental toxicology and pharmacology,2016,46:80-89.
APA Zheng, Zhiyong,Shi, Liang,Sheng, Yuchen,Zhang, Jiaqi,Lu, Bin,&Ji, Lili.(2016).Chlorogenic acid suppresses monocrotaline-induced sinusoidal obstruction syndrome: The potential contribution of NFκB, Egr1, Nrf2, MAPKs and PI3K signals.Environmental toxicology and pharmacology,46,80-89.
MLA Zheng, Zhiyong,et al."Chlorogenic acid suppresses monocrotaline-induced sinusoidal obstruction syndrome: The potential contribution of NFκB, Egr1, Nrf2, MAPKs and PI3K signals".Environmental toxicology and pharmacology 46(2016):80-89.

入库方式: OAI收割

来源:上海药物研究所

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