Chlorogenic acid suppresses monocrotaline-induced sinusoidal obstruction syndrome: The potential contribution of NFκB, Egr1, Nrf2, MAPKs and PI3K signals
文献类型:期刊论文
作者 | Zheng, Zhiyong1; Shi, Liang1; Sheng, Yuchen2; Zhang, Jiaqi1; Lu, Bin1; Ji, Lili1 |
刊名 | Environmental toxicology and pharmacology
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出版日期 | 2016-09 |
卷号 | 46页码:80-89 |
ISSN号 | 1872-7077 |
DOI | 10.1016/j.etap.2016.07.002 |
文献子类 | Article |
英文摘要 | Hepatic sinusoidal obstruction syndrome (SOS) is a highly lethal liver disease. This study aims to observe the protection and its engaged mechanism of chlorogenic acid (CGA) against monocrotaline (MCT)-induced SOS. Results of detecting liver ascites, measuring serum transaminases, liver histological evaluation and scanning electron microscope observation all demonstrated that CGA prevented MCT-induced SOS in rats. CGA reduced MCT-induced increased liver myeloperoxidase (MPO) activity, tumor necrosis factor (TNF)α and interleukin (IL)-1β mRNA expression, toll-like receptor (TLR)-2,3,6,9 expression, and nuclear factor κB (NFκB) transcriptional activation. CGA also decreased MCT-induced early growth response1 (Egr1) activation. CGA reduced MCT-induced elevated liver malondialdehyde (MDA) amount and enhanced nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2). CGA blocked MCT-induced PI3K and MAPKs activation. In conclusion, this study demonstrates the protection of CGA against MCT-induced SOS. Transcriptional factor NFκB, Egr1 and Nrf2-regulated inflammation, coagulation-fibrinolysis, and antioxidant, and PI3K and MAPKs all contribute to such protection. |
语种 | 英语 |
源URL | [http://119.78.100.183/handle/2S10ELR8/266497] ![]() |
专题 | 中国科学院上海药物研究所 |
通讯作者 | Ji, Lili |
作者单位 | 1.Shanghai Key Laboratory of Complex Prescription, MOE Key Laboratory for Standardization of Chinese Medicines, SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China; 2.Center for Drug Safety Evaluation and Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China |
推荐引用方式 GB/T 7714 | Zheng, Zhiyong,Shi, Liang,Sheng, Yuchen,et al. Chlorogenic acid suppresses monocrotaline-induced sinusoidal obstruction syndrome: The potential contribution of NFκB, Egr1, Nrf2, MAPKs and PI3K signals[J]. Environmental toxicology and pharmacology,2016,46:80-89. |
APA | Zheng, Zhiyong,Shi, Liang,Sheng, Yuchen,Zhang, Jiaqi,Lu, Bin,&Ji, Lili.(2016).Chlorogenic acid suppresses monocrotaline-induced sinusoidal obstruction syndrome: The potential contribution of NFκB, Egr1, Nrf2, MAPKs and PI3K signals.Environmental toxicology and pharmacology,46,80-89. |
MLA | Zheng, Zhiyong,et al."Chlorogenic acid suppresses monocrotaline-induced sinusoidal obstruction syndrome: The potential contribution of NFκB, Egr1, Nrf2, MAPKs and PI3K signals".Environmental toxicology and pharmacology 46(2016):80-89. |
入库方式: OAI收割
来源:上海药物研究所
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