Withania somnifera Root Extract Enhances Chemotherapy through 'Priming'
文献类型：期刊论文
| 作者 | Henley, Aine Brigette2; Yang, Ling3; Chuang, Kun-Lin3; Sahuri-Arisoylu, Meliz2; Wu, Li-Hong1; Bligh, S W Annie2; Bell, Jimmy David2 |
| 刊名 | PloS one
 |
| 出版日期 | 2017 |
| 卷号 | 12期号:1页码:e0170917 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0170917 |
| 文献子类 | Article |
| 英文摘要 | Withania somnifera extracts are known for their anti-cancerous, anti-inflammatory and antioxidative properties. One of their mechanisms of actions is to modulate mitochondrial function through increasing oxidative stress. Recently 'priming' has been suggested as a potential mechanism for enhancing cancer cell death. In this study we demonstrate that 'priming', in HT-29 colon cells, with W. somnifera root extract increased the potency of the chemotherapeutic agent cisplatin. We have also showed the W. somnifera root extract enhanced mitochondrial dysfunction and that the underlying mechanism of 'priming' was selectively through increased ROS. Moreover, we showed that this effect was not seen in non-cancerous cells. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266506]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China 2.Department of Life Sciences, Faculty of Science and Technology, University of Westminster, London, United Kingdom; 3.Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung, Taiwan; |
| 推荐引用方式 GB/T 7714 | Henley, Aine Brigette,Yang, Ling,Chuang, Kun-Lin,et al. Withania somnifera Root Extract Enhances Chemotherapy through 'Priming'[J]. PloS one,2017,12(1):e0170917. |
| APA | Henley, Aine Brigette.,Yang, Ling.,Chuang, Kun-Lin.,Sahuri-Arisoylu, Meliz.,Wu, Li-Hong.,...&Bell, Jimmy David.(2017).Withania somnifera Root Extract Enhances Chemotherapy through 'Priming'.PloS one,12(1),e0170917. |
| MLA | Henley, Aine Brigette,et al."Withania somnifera Root Extract Enhances Chemotherapy through 'Priming'".PloS one 12.1(2017):e0170917. |
入库方式： OAI收割
来源：上海药物研究所
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