The gender-dependent difference of liver GSH antioxidant system in mice and its influence on isoline-induced liver injury
文献类型：期刊论文
| 作者 | Liang, Qingning; Sheng, Yuchen; Jiang, Ping; Ji, Lili; Xia, Yuye; Min, Yang; Wang, Zhengtao |
| 刊名 | Toxicology
 |
| 出版日期 | 2011-02-04 |
| 卷号 | 280期号:1-2页码:61-9 |
| ISSN号 | 1879-3185 |
| DOI | 10.1016/j.tox.2010.11.010 |
| 文献子类 | Article |
| 英文摘要 | Intracellular reduced glutathione (GSH) antioxidant system is crucial for counteracting oxidative stress-induced liver injury. The present study was designed to observe the gender-dependent difference of GSH antioxidant system and its influence on hepatotoxic pyrrolizidine alkaloid (HPA) isoline-induced liver injury. Lower activities and protein expressions of glutamate-cysteine ligase (GCL) and glutathione peroxidase (GPx) were found in male mice livers than in female. Isoline is a natural HPA, our further results showed that male mice demonstrated more higher serum ALT/AST levels, less GSH amounts, lower GCL and GPx activities and proteins induced by isoline as compared to female. N-acetyl-l-cysteine (NAC), which is the precursor of cellular GSH biosynthesis, ameliorated liver injury induced by isoline. l-Buthionine-(S, R)-sulfoximine (BSO) and mercaptosuccinic acid (MA), inhibitors of GCL and GPx, both augmented isoline-induced cytotoxicity in cultured mice hepatocytes. BSO and MA also increased other natural HPAs clivorine and senecionine-induced cytotoxicity. Taken together, our results demonstrated the higher GCL and GPx activities in female mice, which indicated their crucial roles in regulating the resistance of liver injury induced by hepatotoxins in female. Meanwhile, our results also revealed the female-resistant liver injury induced by HPAs for the first time. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266522]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China |
| 推荐引用方式 GB/T 7714 | Liang, Qingning,Sheng, Yuchen,Jiang, Ping,et al. The gender-dependent difference of liver GSH antioxidant system in mice and its influence on isoline-induced liver injury[J]. Toxicology,2011,280(1-2):61-9. |
| APA | Liang, Qingning.,Sheng, Yuchen.,Jiang, Ping.,Ji, Lili.,Xia, Yuye.,...&Wang, Zhengtao.(2011).The gender-dependent difference of liver GSH antioxidant system in mice and its influence on isoline-induced liver injury.Toxicology,280(1-2),61-9. |
| MLA | Liang, Qingning,et al."The gender-dependent difference of liver GSH antioxidant system in mice and its influence on isoline-induced liver injury".Toxicology 280.1-2(2011):61-9. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。