中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
The gender-dependent difference of liver GSH antioxidant system in mice and its influence on isoline-induced liver injury

文献类型:期刊论文

作者Liang, Qingning; Sheng, Yuchen; Jiang, Ping; Ji, Lili; Xia, Yuye; Min, Yang; Wang, Zhengtao
刊名Toxicology
出版日期2011-02-04
卷号280期号:1-2页码:61-9
ISSN号1879-3185
DOI10.1016/j.tox.2010.11.010
文献子类Article
英文摘要Intracellular reduced glutathione (GSH) antioxidant system is crucial for counteracting oxidative stress-induced liver injury. The present study was designed to observe the gender-dependent difference of GSH antioxidant system and its influence on hepatotoxic pyrrolizidine alkaloid (HPA) isoline-induced liver injury. Lower activities and protein expressions of glutamate-cysteine ligase (GCL) and glutathione peroxidase (GPx) were found in male mice livers than in female. Isoline is a natural HPA, our further results showed that male mice demonstrated more higher serum ALT/AST levels, less GSH amounts, lower GCL and GPx activities and proteins induced by isoline as compared to female. N-acetyl-l-cysteine (NAC), which is the precursor of cellular GSH biosynthesis, ameliorated liver injury induced by isoline. l-Buthionine-(S, R)-sulfoximine (BSO) and mercaptosuccinic acid (MA), inhibitors of GCL and GPx, both augmented isoline-induced cytotoxicity in cultured mice hepatocytes. BSO and MA also increased other natural HPAs clivorine and senecionine-induced cytotoxicity. Taken together, our results demonstrated the higher GCL and GPx activities in female mice, which indicated their crucial roles in regulating the resistance of liver injury induced by hepatotoxins in female. Meanwhile, our results also revealed the female-resistant liver injury induced by HPAs for the first time.
语种英语
源URL[http://119.78.100.183/handle/2S10ELR8/266522]  
专题中国科学院上海药物研究所
作者单位The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China
推荐引用方式
GB/T 7714
Liang, Qingning,Sheng, Yuchen,Jiang, Ping,et al. The gender-dependent difference of liver GSH antioxidant system in mice and its influence on isoline-induced liver injury[J]. Toxicology,2011,280(1-2):61-9.
APA Liang, Qingning.,Sheng, Yuchen.,Jiang, Ping.,Ji, Lili.,Xia, Yuye.,...&Wang, Zhengtao.(2011).The gender-dependent difference of liver GSH antioxidant system in mice and its influence on isoline-induced liver injury.Toxicology,280(1-2),61-9.
MLA Liang, Qingning,et al."The gender-dependent difference of liver GSH antioxidant system in mice and its influence on isoline-induced liver injury".Toxicology 280.1-2(2011):61-9.

入库方式: OAI收割

来源:上海药物研究所

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