Berberine protects acute liver failure in mice through inhibiting inflammation and mitochondria-dependent apoptosis
文献类型：期刊论文
| 作者 | Xu, Lulu1; Zheng, Xia1; Wang, Yinhang1; Fan, Qilin1; Zhang, Miao1; Li, Ruiyan1; Ye, Junmei1; Wu, Xiaojun2; Zhao, Wenfeng1; Zhang, Yubin1 |
| 刊名 | European journal of pharmacology
 |
| 出版日期 | 2018-01-15 |
| 卷号 | 819页码:161-168 |
| ISSN号 | 1879-0712 |
| DOI | 10.1016/j.ejphar.2017.11.013 |
| 文献子类 | Article |
| 英文摘要 | Acute liver failure (ALF) is characterized by sudden large area of inflammation and extensive hepatocyte apoptosis. This study identified the natural product berberine as a potential agent for acute liver failure(ALF). First, in vitro, BBR pre-incubation (5, 10 and 20μM) alleviated L02 hepatocytes injury induced by D-GalN (5mM)/TNF-α (100ng/ml). Second, in vivo, BBR pre-treatment attenuated D-Galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced acute liver failure, as evidenced by the reduction of mortality, the alleviation of liver pathological changes and the inhibition of alanine aminotransferase (ALT)/aspartate aminotransferase (AST). Our results further illustrated that BBR inhibited the nuclear translocation of NF-κB p65 and subsequently suppressed the expressions of inflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) at both mRNA and protein levels in ALF. Moreover, western blotting demonstrated that BBR effectively inhibited apoptosis via reducing cytochrome c release, Bax/Bcl-2 ratio and caspase-3/-9 cleavage in vitro and in vivo. In conclusion, our findings suggest that BBR serves as a potential agent for preventing or treating human ALF by inhibiting inflammation and mitochondria-dependent apoptosis. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266529]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Yubin |
| 作者单位 | 1.State Key Laboratory of Natural Medicines, Department of Biochemistry, China Pharmaceutical University, China; 2.Shanghai Key Laboratory of Complex Prescription, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
| 推荐引用方式 GB/T 7714 | Xu, Lulu,Zheng, Xia,Wang, Yinhang,et al. Berberine protects acute liver failure in mice through inhibiting inflammation and mitochondria-dependent apoptosis[J]. European journal of pharmacology,2018,819:161-168. |
| APA | Xu, Lulu.,Zheng, Xia.,Wang, Yinhang.,Fan, Qilin.,Zhang, Miao.,...&Zhang, Yubin.(2018).Berberine protects acute liver failure in mice through inhibiting inflammation and mitochondria-dependent apoptosis.European journal of pharmacology,819,161-168. |
| MLA | Xu, Lulu,et al."Berberine protects acute liver failure in mice through inhibiting inflammation and mitochondria-dependent apoptosis".European journal of pharmacology 819(2018):161-168. |
入库方式： OAI收割
来源：上海药物研究所
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