Metabolomic and genomic evidence for compromised bile acid homeostasis by senecionine, a hepatotoxic pyrrolizidine alkaloid
文献类型：期刊论文
| 作者 | Xiong, Aizhen; Yang, Fan; Fang, Lianxiang; Yang, Li; He, Yuqi; Wan, Yu-Jui Yvonne; Wan, Yvonne Yu-Jui; Xu, Ying; Qi, Meng; Wang, Xiuli |
| 刊名 | Chemical research in toxicology
 |
| 出版日期 | 2014-05-19 |
| 卷号 | 27期号:5页码:775-86 |
| ISSN号 | 1520-5010 |
| DOI | 10.1021/tx400451q |
| 文献子类 | Article |
| 英文摘要 | Pyrrolizidine alkaloids (PAs) are among the most hepatotoxic natural products that produce irreversible injury to humans via the consumption of herbal medicine and honey, and through tea preparation. Toxicity and death caused by PA exposure have been reported worldwide. Metabolomics and genomics provide scientific and systematic views of a living organism and have become powerful techniques for toxicology research. In this study, senecionine hepatotoxicity on rats was determined via a combination of metabolomic and genomic analyses. From the global analysis generated from two omics data, the compromised bile acid homeostasis in vivo was innovatively demonstrated and confirmed. Serum profiling of bile acids was altered with significantly elevated conjugated bile acids after senecionine exposure, which was in accordance with toxicity. Similarly, the hepatic mRNA levels of several key genes associated with bile acid metabolism were significantly changed. This process included cholesterol 7-α hydroxylase, bile acid CoA-amino acid N-acetyltransferase, sodium taurocholate cotransporting polypeptide, organic anion-transporting polypeptides, and multidrug-resistance-associated protein 3. In conclusion, a cross-omics study provides a comprehensive analysis method for studying the toxicity caused by senecionine, which is a hepatotoxic PA. Moreover, the change in bile acid metabolism and the respective transporters may provide a new PA toxicity mechanism. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266541]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine , 1200 Cailun Road, Shanghai 201203, China |
| 推荐引用方式 GB/T 7714 | Xiong, Aizhen,Yang, Fan,Fang, Lianxiang,et al. Metabolomic and genomic evidence for compromised bile acid homeostasis by senecionine, a hepatotoxic pyrrolizidine alkaloid[J]. Chemical research in toxicology,2014,27(5):775-86. |
| APA | Xiong, Aizhen.,Yang, Fan.,Fang, Lianxiang.,Yang, Li.,He, Yuqi.,...&Wang, Zhengtao.(2014).Metabolomic and genomic evidence for compromised bile acid homeostasis by senecionine, a hepatotoxic pyrrolizidine alkaloid.Chemical research in toxicology,27(5),775-86. |
| MLA | Xiong, Aizhen,et al."Metabolomic and genomic evidence for compromised bile acid homeostasis by senecionine, a hepatotoxic pyrrolizidine alkaloid".Chemical research in toxicology 27.5(2014):775-86. |
入库方式： OAI收割
来源：上海药物研究所
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