Structure of a homofructosan from Saussurea costus and anti-complementary activity of its sulfated derivatives
文献类型：期刊论文
| 作者 | Fan, Hongwei2; Liu, Fei2; Bligh, S W Annie1; Shi, Songshan2; Wang, Shunchun2 |
| 刊名 | Carbohydrate polymers
 |
| 出版日期 | 2014-05-25 |
| 卷号 | 105页码:152-60 |
| ISSN号 | 1879-1344 |
| DOI | 10.1016/j.carbpol.2014.01.084 |
| 文献子类 | Article |
| 英文摘要 | A homogeneous water-soluble polysaccharide APS-W1, (2→1)-β-d-fructofuranosan, with an average molecular weight of 3.9kDa, was isolated and characterized from the roots of Saussurea costus. Five sulfated derivatives of APS-W1 with different degrees of sulfation were prepared and they showed strong inhibitory effect on the complement activation through the classical pathway (CP50: 2.2-18.9μg/mL; 8.3μg/mL for heparin) and alternative pathway (AP50: 11.4-115.8μg/mL; 89.2μg/mL for heparin). Mechanism studies by using complement-depleted sera indicated that sulfated derivatives with different positions of sulfation targeted to different complement proteins. Meanwhile the sulfated derivatives have limited anticoagulant effect based on re-calcification time and thrombin time. These results suggested that the sulfated derivatives prepared from APS-W1 could be promising potential complement inhibitors for the treatment of diseases caused by an over-activated complement system. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266571]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Bligh, S W Annie; Wang, Shunchun |
| 作者单位 | 1.Department of Complementary Medicine, Faculty of Science and Technology, University of Westminster, London W1W 6UW, UK 2.The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; |
| 推荐引用方式 GB/T 7714 | Fan, Hongwei,Liu, Fei,Bligh, S W Annie,et al. Structure of a homofructosan from Saussurea costus and anti-complementary activity of its sulfated derivatives[J]. Carbohydrate polymers,2014,105:152-60. |
| APA | Fan, Hongwei,Liu, Fei,Bligh, S W Annie,Shi, Songshan,&Wang, Shunchun.(2014).Structure of a homofructosan from Saussurea costus and anti-complementary activity of its sulfated derivatives.Carbohydrate polymers,105,152-60. |
| MLA | Fan, Hongwei,et al."Structure of a homofructosan from Saussurea costus and anti-complementary activity of its sulfated derivatives".Carbohydrate polymers 105(2014):152-60. |
入库方式： OAI收割
来源：上海药物研究所
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