Modeling vertical transmission of HIV: imperfect vaccines can be of benefit
文献类型：期刊论文
| 作者 | Sim, Myung Shin K; Cumberland, William G; Duan, Naihua; Bryson, Yvonne J |
| 刊名 | Vaccine
 |
| 出版日期 | 2009-11-23 |
| 卷号 | 27期号:50页码:7003-10 |
| ISSN号 | 1873-2518 |
| DOI | 10.1016/j.vaccine.2009.09.074 |
| 文献子类 | Article |
| 英文摘要 | Reducing mother to child transmission (MTCT) of HIV in resource poor countries continues to be a major challenge. Here, we construct a hazard model to assess the effectiveness of combinations of HIV vaccine, Nevirapine (NVP), and HIV-specific monoclonal antibody (HIVAB) in reducing MTCT of HIV during the intrapartum and breastfeeding periods. The model shows that an intervention that uses three doses of vaccine with 30% initial immunity and 30% boost effect with subsequent doses (giving rise to maximum immunity approximately 66% with 3 doses) could reduce MTCT to 7.7% when used with NVP and to 5.9% when used with NVP and HIVAB. Using a vaccine with 50% initial immunity and 50% boost can reduce the rate to 4.3%. These results indicate that even an imperfect vaccine, when used in combination with other therapies, can be of considerable benefit in preventing MTCT in resource poor countries. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266598]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Sim, Myung Shin K |
| 作者单位 | Department of Biostatistics, John Wayne Cancer Institute, Santa Monica, CA 90404, United States |
| 推荐引用方式 GB/T 7714 | Sim, Myung Shin K,Cumberland, William G,Duan, Naihua,et al. Modeling vertical transmission of HIV: imperfect vaccines can be of benefit[J]. Vaccine,2009,27(50):7003-10. |
| APA | Sim, Myung Shin K,Cumberland, William G,Duan, Naihua,&Bryson, Yvonne J.(2009).Modeling vertical transmission of HIV: imperfect vaccines can be of benefit.Vaccine,27(50),7003-10. |
| MLA | Sim, Myung Shin K,et al."Modeling vertical transmission of HIV: imperfect vaccines can be of benefit".Vaccine 27.50(2009):7003-10. |
入库方式： OAI收割
来源：上海药物研究所
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