中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Chemical constituents with anti-allergic activity from the root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora

文献类型:期刊论文

作者Shi, Yan-Hong5; Zhu, Shu5; Tamura, Takayuki2; Kadowaki, Makoto1; Wang, Zhengtao4; Yoshimatsu, Kayo3; Komatsu, Katsuko5
刊名Journal of natural medicines
出版日期2016-04
卷号70期号:2页码:234-40
ISSN号1861-0293
DOI10.1007/s11418-016-0966-4
文献子类Article
英文摘要The methanolic extract and its subfractions from the dried root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora Pallas, showed potent anti-allergic effect as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 26 compounds, including a new norneolignan glycoside, paeonibenzofuran (1), together with 25 known ones (2-26). The chemical structure of the new compound was elucidated on the basis of spectroscopic and chemical evidences. Among the isolated compounds, mudanpioside E (5) with paeoniflorin-type skeleton and quercetin (16) showed potent inhibitory activity against a degranulation marker, β-hexosaminidase release with IC50 values of 40.34 and 25.05 μM, respectively. A primary structure-activity relationship of these components was discussed.
语种英语
源URL[http://119.78.100.183/handle/2S10ELR8/266644]  
专题中国科学院上海药物研究所
通讯作者Zhu, Shu; Komatsu, Katsuko
作者单位1.Division of Gastrointestinal Pathophysiology, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, 930-0194, Japan;
2.Toyama Prefectural Medicinal Plants Center, Toyama, 930-0412, Japan;
3.Research Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, 305-0843, Japan
4.The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China;
5.Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan;
推荐引用方式
GB/T 7714
Shi, Yan-Hong,Zhu, Shu,Tamura, Takayuki,et al. Chemical constituents with anti-allergic activity from the root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora[J]. Journal of natural medicines,2016,70(2):234-40.
APA Shi, Yan-Hong.,Zhu, Shu.,Tamura, Takayuki.,Kadowaki, Makoto.,Wang, Zhengtao.,...&Komatsu, Katsuko.(2016).Chemical constituents with anti-allergic activity from the root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora.Journal of natural medicines,70(2),234-40.
MLA Shi, Yan-Hong,et al."Chemical constituents with anti-allergic activity from the root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora".Journal of natural medicines 70.2(2016):234-40.

入库方式: OAI收割

来源:上海药物研究所

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