Chemical constituents with anti-allergic activity from the root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora
文献类型：期刊论文
| 作者 | Shi, Yan-Hong5 ; Zhu, Shu5; Tamura, Takayuki2; Kadowaki, Makoto1; Wang, Zhengtao4; Yoshimatsu, Kayo3; Komatsu, Katsuko5
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| 刊名 | Journal of natural medicines
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| 出版日期 | 2016-04 |
| 卷号 | 70期号:2页码:234-40 |
| ISSN号 | 1861-0293 |
| DOI | 10.1007/s11418-016-0966-4 |
| 文献子类 | Article |
| 英文摘要 | The methanolic extract and its subfractions from the dried root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora Pallas, showed potent anti-allergic effect as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 26 compounds, including a new norneolignan glycoside, paeonibenzofuran (1), together with 25 known ones (2-26). The chemical structure of the new compound was elucidated on the basis of spectroscopic and chemical evidences. Among the isolated compounds, mudanpioside E (5) with paeoniflorin-type skeleton and quercetin (16) showed potent inhibitory activity against a degranulation marker, β-hexosaminidase release with IC50 values of 40.34 and 25.05 μM, respectively. A primary structure-activity relationship of these components was discussed. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266644]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhu, Shu; Komatsu, Katsuko |
| 作者单位 | 1.Division of Gastrointestinal Pathophysiology, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, 930-0194, Japan; 2.Toyama Prefectural Medicinal Plants Center, Toyama, 930-0412, Japan; 3.Research Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, 305-0843, Japan 4.The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; 5.Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan; |
| 推荐引用方式 GB/T 7714 | Shi, Yan-Hong,Zhu, Shu,Tamura, Takayuki,et al. Chemical constituents with anti-allergic activity from the root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora[J]. Journal of natural medicines,2016,70(2):234-40. |
| APA | Shi, Yan-Hong.,Zhu, Shu.,Tamura, Takayuki.,Kadowaki, Makoto.,Wang, Zhengtao.,...&Komatsu, Katsuko.(2016).Chemical constituents with anti-allergic activity from the root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora.Journal of natural medicines,70(2),234-40. |
| MLA | Shi, Yan-Hong,et al."Chemical constituents with anti-allergic activity from the root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora".Journal of natural medicines 70.2(2016):234-40. |
入库方式： OAI收割
来源：上海药物研究所
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