Protein glycation during aging and in cardiovascular disease
文献类型：期刊论文
| 作者 | Simm, Andreas |
| 刊名 | Journal of proteomics
 |
| 出版日期 | 2013-10-30 |
| 卷号 | 92页码:248-59 |
| ISSN号 | 1876-7737 |
| DOI | 10.1016/j.jprot.2013.05.012 |
| 文献子类 | Article;Review |
| 英文摘要 | Advanced glycation endproducts (AGEs), pathophysiological important posttranslational modifications, are formed in vivo by a non-enzymatic reaction of proteins with reactive carbohydrates and accumulate during aging. They are discussed to be responsible for degenerative diseases. Glycation modifies the structure and function of proteins, induces tissue stiffening via crosslinking and a long-lasting inflammatory response after binding to AGE-receptors. Beside the extracellular matrix, a couple of intracellular proteins are known to be glycated leading to molecular and cellular dysfunction. In the cardiovascular system, AGEs are a major cause of cardiac and vascular dysfunction. Whereas AGEs are discussed to be potential biomarkers for diseases as well as for aging, the molecular analysis of AGEs in body fluids and tissue has still to be further improved. This article is part of a Special Issue entitled: Posttranslational Protein modifications in biology and Medicine. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266655]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Simm, Andreas |
| 作者单位 | Department of Cardiothoracic Surgery, University Hospital Halle, Ernst-Grube Str. 40, D-06120 Halle (Saale), Germany |
| 推荐引用方式 GB/T 7714 | Simm, Andreas. Protein glycation during aging and in cardiovascular disease[J]. Journal of proteomics,2013,92:248-59. |
| APA | Simm, Andreas.(2013).Protein glycation during aging and in cardiovascular disease.Journal of proteomics,92,248-59. |
| MLA | Simm, Andreas."Protein glycation during aging and in cardiovascular disease".Journal of proteomics 92(2013):248-59. |
入库方式： OAI收割
来源：上海药物研究所
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