Bile acid nuclear receptor FXR and digestive system diseases
文献类型：期刊论文
| 作者 | Ding, Lili1,2; Yang, Li3; Wang, Zhengtao3; Huang, Wendong4 |
| 刊名 | Acta pharmaceutica Sinica. B
 |
| 出版日期 | 2015-03 |
| 卷号 | 5期号:2页码:135-44 |
| ISSN号 | 2211-3835 |
| DOI | 10.1016/j.apsb.2015.01.004 |
| 文献子类 | Article;Review |
| 英文摘要 | Bile acids (BAs) are not only digestive surfactants but also important cell signaling molecules, which stimulate several signaling pathways to regulate some important biological processes. The bile-acid-activated nuclear receptor, farnesoid X receptor (FXR), plays a pivotal role in regulating bile acid, lipid and glucose homeostasis as well as in regulating the inflammatory responses, barrier function and prevention of bacterial translocation in the intestinal tract. As expected, FXR is involved in the pathophysiology of a wide range of diseases of gastrointestinal tract, including inflammatory bowel disease, colorectal cancer and type 2 diabetes. In this review, we discuss current knowledge of the roles of FXR in physiology of the digestive system and the related diseases. Better understanding of the roles of FXR in digestive system will accelerate the development of FXR ligands/modulators for the treatment of digestive system diseases. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266660]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Shanghai Key Laboratory of Complex Prescriptions and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China ; 2.Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA; 3.Shanghai Key Laboratory of Complex Prescriptions and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; 4.Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA |
| 推荐引用方式 GB/T 7714 | Ding, Lili,Yang, Li,Wang, Zhengtao,et al. Bile acid nuclear receptor FXR and digestive system diseases[J]. Acta pharmaceutica Sinica. B,2015,5(2):135-44. |
| APA | Ding, Lili,Yang, Li,Wang, Zhengtao,&Huang, Wendong.(2015).Bile acid nuclear receptor FXR and digestive system diseases.Acta pharmaceutica Sinica. B,5(2),135-44. |
| MLA | Ding, Lili,et al."Bile acid nuclear receptor FXR and digestive system diseases".Acta pharmaceutica Sinica. B 5.2(2015):135-44. |
入库方式： OAI收割
来源：上海药物研究所
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