Stress and biological aging: A double-edged sword
文献类型：期刊论文
| 作者 | Simm, Andreas; Klotz, Lars-Oliver |
| 刊名 | Zeitschrift fur Gerontologie und Geriatrie
 |
| 出版日期 | 2015-08 |
| 卷号 | 48期号:6页码:505-10 |
| ISSN号 | 1435-1269 |
| DOI | 10.1007/s00391-015-0928-6 |
| 文献子类 | Article |
| 英文摘要 | It is well accepted that aging is the basis of most degenerative diseases in the elderly. Biological aging is characterized by a gradual accumulation of cellular and molecular defects. An important cause of defects is intense stress, such as oxidative or glycotoxic stress. Genes affecting cellular and organismal longevity are frequently associated with the regulation of cellular anti-oxidative defense and/or with repair functions. Damage, combined with an age-dependent decline in defense and repair systems, results in disturbed homeostasis, leading to aging and diseases. Whereas intense stress induces premature aging, mild stress can induce adaptive processes, stimulating the expression of genetic repair/defense systems, which positively influences life span. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266670]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Simm, Andreas |
| 作者单位 | Heart Centre of the University Hospital Halle (Saale), Martin-Luther University Halle-Wittenberg, Ernst-Grube Str. 40, 06120, Halle (Saale), Germany, andreas |
| 推荐引用方式 GB/T 7714 | Simm, Andreas,Klotz, Lars-Oliver. Stress and biological aging: A double-edged sword[J]. Zeitschrift fur Gerontologie und Geriatrie,2015,48(6):505-10. |
| APA | Simm, Andreas,&Klotz, Lars-Oliver.(2015).Stress and biological aging: A double-edged sword.Zeitschrift fur Gerontologie und Geriatrie,48(6),505-10. |
| MLA | Simm, Andreas,et al."Stress and biological aging: A double-edged sword".Zeitschrift fur Gerontologie und Geriatrie 48.6(2015):505-10. |
入库方式： OAI收割
来源：上海药物研究所
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