Protein glycation - Between tissue aging and protection
文献类型：期刊论文
| 作者 | Simm, Andreas; Müller, Beatrice; Nass, Norbert; Hofmann, Britt; Bushnaq, Hasan; Silber, Rolf-Edgar; Bartling, Babett |
| 刊名 | Experimental gerontology
 |
| 出版日期 | 2015-08 |
| 卷号 | 68页码:71-5 |
| ISSN号 | 1873-6815 |
| DOI | 10.1016/j.exger.2014.12.013 |
| 文献子类 | Article;Review |
| 英文摘要 | Non-enzymatic formation of advanced glycation endproducts (AGEs) is associated with degenerative diseases. Chronic accumulation of AGEs with age in tissues especially in the extracellular matrix is well known and at least in part responsible for e.g., collagen crosslinking, tissue stiffening and thus induction of high blood pressure or diastolic heart failure. Binding of soluble AGEs to the receptor for AGEs, RAGE, induces an inflammatory response whereas the soluble form of RAGE (sRAGE) can inhibit inflammatory tissue injury like arteriosclerosis in mouse models. However, there are a number of indications that AGEs have protective effects as well. AGEs may inhibit lung tumor growth, glyoxal induced AGE modification of human heart muscle can reduce an ischemia reperfusion injury and AGEs from nutrition can reduce ROS induced cell damage. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266678]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Simm, Andreas |
| 作者单位 | Cardiothoracic Surgery, Martin Luther University Halle-Wittenberg, Halle/Saale, Germany |
| 推荐引用方式 GB/T 7714 | Simm, Andreas,Müller, Beatrice,Nass, Norbert,et al. Protein glycation - Between tissue aging and protection[J]. Experimental gerontology,2015,68:71-5. |
| APA | Simm, Andreas.,Müller, Beatrice.,Nass, Norbert.,Hofmann, Britt.,Bushnaq, Hasan.,...&Bartling, Babett.(2015).Protein glycation - Between tissue aging and protection.Experimental gerontology,68,71-5. |
| MLA | Simm, Andreas,et al."Protein glycation - Between tissue aging and protection".Experimental gerontology 68(2015):71-5. |
入库方式： OAI收割
来源：上海药物研究所
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