Plantago asiatica L. Seed Extract Improves Lipid Accumulation and Hyperglycemia in High-Fat Diet-Induced Obese Mice
文献类型：期刊论文
| 作者 | Yang, Qiming1; Qi, Meng1; Tong, Renchao1; Wang, Dandan1; Ding, Lili1; Li, Zeyun1; Huang, Cheng2; Wang, Zhengtao1; Yang, Li1 |
| 刊名 | International journal of molecular sciences
 |
| 出版日期 | 2017-06-30 |
| 卷号 | 18期号:7 |
| ISSN号 | 1422-0067 |
| DOI | 10.3390/ijms18071393 |
| 文献子类 | Article |
| 英文摘要 | Obesity and its common association with type 2 diabetes, dyslipidemia, and cardiovascular diseases are worldwide epidemics. Currently, to prevent or treat obesity and associated metabolic disorders, herbal dietary supplements or medicines have attracted more and more attention owing to their relative effectiveness with fewer significant side effects. We investigate the therapeutic effects and underlying mechanisms of L. seed extract (PSE) on obesity and associated metabolic disorders in high-fat (HF) diet-induced mice. Our results displayed that PSE did not modify food intake or body weight but decreased abdominal white adipose tissue ratio, white/brown adipocyte size, serum total cholesterol, triglyceride (TG), low density lipoprotein cholesterol, free fatty acid, and hepatic TG concentrations when compared with the HF group. The levels of fasting blood glucose and glucose tolerance were improved in the PSE group when compared with the HF group. Furthermore, PSE upregulated mRNA expressions of peroxisome proliferator activated receptors (PPARs) and target genes related to fatty acid metabolism and energy expenditure in liver and adipose tissue of obese mice when compared with the HF group. PSE treatment effectively improved lipid and glucose metabolism in HF diet-induced obese mice. These effects might be attributed to the upregulation of PPAR signaling. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266695]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yang, Qiming; Qi, Meng; Tong, Renchao; Wang, Dandan; Ding, Lili; Li, Zeyun; Huang, Cheng; Wang, Zhengtao; Yang, Li |
| 作者单位 | 1.The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines and the State Administration of Traditional Chinese Medicine (SATCM) Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; 2.School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. chuang |
| 推荐引用方式 GB/T 7714 | Yang, Qiming,Qi, Meng,Tong, Renchao,et al. Plantago asiatica L. Seed Extract Improves Lipid Accumulation and Hyperglycemia in High-Fat Diet-Induced Obese Mice[J]. International journal of molecular sciences,2017,18(7). |
| APA | Yang, Qiming.,Qi, Meng.,Tong, Renchao.,Wang, Dandan.,Ding, Lili.,...&Yang, Li.(2017).Plantago asiatica L. Seed Extract Improves Lipid Accumulation and Hyperglycemia in High-Fat Diet-Induced Obese Mice.International journal of molecular sciences,18(7). |
| MLA | Yang, Qiming,et al."Plantago asiatica L. Seed Extract Improves Lipid Accumulation and Hyperglycemia in High-Fat Diet-Induced Obese Mice".International journal of molecular sciences 18.7(2017). |
入库方式： OAI收割
来源：上海药物研究所
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