Biocompatible Stimuli-Responsive W/O/W Multiple Emulsions Prepared by One-Step Mixing with a Single Diblock Copolymer Emulsifier
文献类型：期刊论文
| 作者 | Protat, Marine2; Bodin, Noémie2; Gobeaux, Frédéric1; Malloggi, Florent1; Daillant, Jean3; Pantoustier, Nadège2; Guenoun, Patrick1; Perrin, Patrick2 |
| 刊名 | Langmuir : the ACS journal of surfaces and colloids
 |
| 出版日期 | 2016-09-22 |
| ISSN号 | 1520-5827 |
| DOI | 10.1021/acs.langmuir.6b02590 |
| 文献子类 | Article |
| 英文摘要 | Multiple water-in-oil-in-water (W/O/W) emulsions are promising materials in designing carriers of hydrophilic molecules or drug delivery systems, provided stability issues are solved and biocompatible chemicals can be used. In this work, we designed a biocompatible amphiphilic copolymer, poly(dimethylsiloxane)-b-poly(2-(dimethylamino)ethyl methacrylate) (PDMS-b-PDMAEMA), that can stabilize emulsions made with various biocompatible oils. The hydrophilic/hydrophobic properties of the copolymer can be adjusted using both pH and ionic strength stimuli. Consequently, the making of O/W (oil in water), W/O (water in oil), and W/O/W emulsions can be achieved by sweeping the pH and ionic strength. Of importance, W/O/W emulsions are formulated over a large pH and ionic strength domain in a one-step emulsification process via transitional phase inversion and are stable for several months. Cryo-TEM and interfacial tension studies show that the formation of these W/O/W emulsions is likely to be correlated to the interfacial film curvature and microemulsion morphology. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266772]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.LIONS, NIMBE, CEA, CNRS, Université Paris-Saclay , CEA Saclay, 91191 Gif-sur-Yvette Cedex, France; 2.Sciences et Ingénierie de la Matière Molle, UMR CNRS 7615, ESPCI ParisTech, PSL Research University , 10 rue Vauquelin, Paris 75005, France; 3.Synchrotron Soleil, L'Orme des Merisiers, Saint-Aubin - BP 48, 91192 Gif-sur-Yvette Cedex, France |
| 推荐引用方式 GB/T 7714 | Protat, Marine,Bodin, Noémie,Gobeaux, Frédéric,et al. Biocompatible Stimuli-Responsive W/O/W Multiple Emulsions Prepared by One-Step Mixing with a Single Diblock Copolymer Emulsifier[J]. Langmuir : the ACS journal of surfaces and colloids,2016. |
| APA | Protat, Marine.,Bodin, Noémie.,Gobeaux, Frédéric.,Malloggi, Florent.,Daillant, Jean.,...&Perrin, Patrick.(2016).Biocompatible Stimuli-Responsive W/O/W Multiple Emulsions Prepared by One-Step Mixing with a Single Diblock Copolymer Emulsifier.Langmuir : the ACS journal of surfaces and colloids. |
| MLA | Protat, Marine,et al."Biocompatible Stimuli-Responsive W/O/W Multiple Emulsions Prepared by One-Step Mixing with a Single Diblock Copolymer Emulsifier".Langmuir : the ACS journal of surfaces and colloids (2016). |
入库方式： OAI收割
来源：上海药物研究所
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