Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway
文献类型:期刊论文
作者 | Li, Lei2; Huang, Wenxiang1; Wang, Shoukai1; Sun, Kecheng1; Zhang, Wenxue1; Ding, Yanmei1; Zhang, Le1; Tumen, Bayaer3; Ji, Lili2; Liu, Chang1 |
刊名 | Molecules (Basel, Switzerland) |
出版日期 | 2018-08-14 |
卷号 | 23期号:8 |
ISSN号 | 1420-3049 |
DOI | 10.3390/molecules23082032 |
文献子类 | Article |
英文摘要 | Acetaminophen (APAP) is a well-known antipyretic and analgesic drug. However, the accidental or intentional APAP overdose will induce liver injury and even acute liver failure. Astragaloside IV (AS-IV), a bioactive compound isolated from Astragali Radix, has been reported to have protective effects on the digestive and immune systems because of its anti-oxidant and anti-inflammatory properties. This study aims to observe whether AS-IV pretreatment provides protection against APAP-induced liver failure. The results of serum alanine/aspartate aminotransferases (ALT/AST) analysis, hepatic glutathione (GSH), and malondialdehyde (MDA) amounts, and liver superoxide dismutase (SOD) activity showed that AS-IV protected against APAP-induced hepatotoxicity. Liver histological observation further evidenced this protection provided by AS-IV. AS-IV was found to reverse the APAP-induced increased amounts of pro-inflammatory cytokines, including interleukin 1β (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α). Western-blot analysis showed that AS-IV increased the transcriptional activation of nuclear factor erythroid 2-related factor 2 (Nrf2), and enhanced the expression of heme oxygenase 1 (HO-1) and reduced nicotinamide adenine dinucleotide phosphate (NAD(P)H): quinone oxidoreductase 1 (NQO1) in the presence of APAP. AS-IV also decreased the expression of kelch-like ECH-associated protein-1 (Keap1). In conclusion, we demonstrated that AS-IV exerted a strong protection against APAP-induced hepatotoxicity by activating Nrf2 antioxidant signaling pathways. |
语种 | 英语 |
源URL | [http://119.78.100.183/handle/2S10ELR8/266773] |
专题 | 中国科学院上海药物研究所 |
通讯作者 | Li, Lei; Huang, Wenxiang; Wang, Shoukai; Sun, Kecheng; Zhang, Wenxue; Ding, Yanmei; Zhang, Le; Tumen, Bayaer; Ji, Lili; Liu, Chang |
作者单位 | 1.Key Laboratory of Quality & Safety Control for Pork, Ministry of Agriculture and Rural, College of Animal Science, Anhui Science and Technology University, Fengyang 233100, China; 2.The Shanghai Key Laboratory of Compound Chinese Medicines and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; 3.Veterinary Laboratory, Shanxi Animal Disease Control Center, Taiyuan 030027, China |
推荐引用方式 GB/T 7714 | Li, Lei,Huang, Wenxiang,Wang, Shoukai,et al. Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway[J]. Molecules (Basel, Switzerland),2018,23(8). |
APA | Li, Lei.,Huang, Wenxiang.,Wang, Shoukai.,Sun, Kecheng.,Zhang, Wenxue.,...&Liu, Chang.(2018).Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway.Molecules (Basel, Switzerland),23(8). |
MLA | Li, Lei,et al."Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway".Molecules (Basel, Switzerland) 23.8(2018). |
入库方式: OAI收割
来源:上海药物研究所
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