Progress in the fragment-based drug discovery
文献类型：会议论文
| 作者 | Ren, Jing; Li, Jian; Shi, Feng; Wang, Xin ; He, Jian-Hua; Xu, Ye-Chun; Zhang, Nai-Xia; Xiong, Bing; Shen, Jing-Kang
|
| 出版日期 | 2013-01 |
| 卷号 | 48 |
| 期号 | 1 |
| 页码 | 14-24 |
| 英文摘要 | As an extension of the structure-based drug discovery, fragment-based drug discovery is matured increasingly, and plays an important role in drug development. Fragments in a small library, with lower molecular mass and high "ligand efficiency", are detected by SPR, MS, NMR, X-ray crystallography technologies and other biophysical methods. Then they are considered as starting points for chemical optimization with the guidance of structural biology methods to get good "drug-like" lead and candidate compounds. In this article, we reviewed the current progress of fragment-based drug discovery and detailed a number of examples to illustrate the novel strategies. |
| 会议录 | Yao xue xue bao = Acta pharmaceutica Sinica
 |
| 文献子类 | Meeting Abstract;Article;Review |
| 语种 | 中文 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266883]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China |
| 推荐引用方式 GB/T 7714 | Ren, Jing,Li, Jian,Shi, Feng,et al. Progress in the fragment-based drug discovery[C]. 见:. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。