The basement membrane and metastasis
文献类型：会议论文
| 作者 | Zhou, Jin; Cheng, Yi; Ding, Jian
|
| 出版日期 | 2006-10 |
| 卷号 | 37 |
| 期号 | 4 |
| 页码 | 307-12 |
| 英文摘要 | The basement membrane (BM) is a specialised form of extracellular matrix (ECM) , which is a major barrier to tumor cells during metastasis. The component of basement membrane plays important role in regulating tumor metastasis by interacting with cell surface receptor integrins. On the other hand, tumor cells secrete Matrix metalloproteinase and Heparanase to degrade the extracellular matrix components, as well as adjust the expression of surface receptor-integrins to facilitate migration in basement membrane and adhesion to target organs. Understanding of the cell-ECM interaction may offer us new strategy for drug discovery. |
| 会议录 | Sheng li ke xue jin zhan [Progress in physiology]
 |
| 文献子类 | Meeting Abstract;Article |
| 语种 | 中文 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266941]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | Division of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Shanghai 201203, China |
| 推荐引用方式 GB/T 7714 | Zhou, Jin,Cheng, Yi,Ding, Jian. The basement membrane and metastasis[C]. 见:. |
入库方式： OAI收割
来源：上海药物研究所
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