Effective cancer immunotherapy by Ganoderma lucidum polysaccharide-gold nanocomposites through dendritic cell activation and memory T cell response
文献类型：期刊论文
| 作者 | Zhang, Shulei1,2; Pang, Guibin1,2; Chen, Chao4; Qin, Jianzhong5; Yu, Huan3; Liu, Yongming3; Zhang, Xihui3; Song, Zhentao7; Zhao, Jian7 ; Wang, Fujun1,2,6
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| 刊名 | Carbohydrate Polymers
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| 出版日期 | 2019-02-01 |
| 卷号 | 205页码:192-202 |
| ISSN号 | 01448617 |
| DOI | 10.1016/j.carbpol.2018.10.028 |
| 文献子类 | Article |
| 英文摘要 | Polysaccharides purified from natural herbs possess immunoregulatory functions, while the efficacy of natural polysaccharides on cancer treatment remains unreliable, likely due to their low prescribed doses and fast clearances in clinical settings. In this study, gold nanocomposites containing Ganoderma lucidum polysaccharide (GLP-Au) efficiently induced dendritic cell (DC) activation, evident by the increase of CD80/CD86/CD40/MHCII, decrease of phagocytic ability and acid phosphatase activity, and increased cytokine transcription. GLP-Au significantly promoted the proliferation of CD4+ and CD8+ T cells in splenocytes. DC/T cell co-culture study proved that GLP-Au activation on DC directly resulted in T cell proliferation. GLP-Au exhibited strong inhibitory effects on 4T1 tumor growth and pulmonary metastasis when combined with doxorubicin. GLP-Au recovered body weight loss by doxorubicin and increased the percentage of CD4+/CD44+ memory T cells. This work suggests that polysaccharides from natural herbs can be incorporated into nanocomposites with immunoregulatory characteristics for enhanced efficacy on tumor therapy. |
| 语种 | 英语 |
| 出版者 | Elsevier Ltd |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266960]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Fujun |
| 作者单位 | 1.State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai; 200237, China; 2.Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai; 201203, China; 3.School for Radiological and Interdisciplinary Sciences 4., State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou; 215123, China; 5.Department of General Surgery, Changshu No. 2 People's Hospital, Changshu; 215500, China; 6.Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou; 215007, China; 7.Zhejiang Reachall Pharmaceutical Co., Ltd., Dongyang; Zhejiang; 322100, China; 8.Shanghai R&D Centre for Standardization of Chinese Medicines, Shanghai; 201210, China; 9.College of Radiation Medicine and Protection, Soochow University, 199 Renai Road, Suzhou, China |
| 推荐引用方式 GB/T 7714 | Zhang, Shulei,Pang, Guibin,Chen, Chao,et al. Effective cancer immunotherapy by Ganoderma lucidum polysaccharide-gold nanocomposites through dendritic cell activation and memory T cell response[J]. Carbohydrate Polymers,2019,205:192-202. |
| APA | Zhang, Shulei.,Pang, Guibin.,Chen, Chao.,Qin, Jianzhong.,Yu, Huan.,...&Zhang, Leshuai W..(2019).Effective cancer immunotherapy by Ganoderma lucidum polysaccharide-gold nanocomposites through dendritic cell activation and memory T cell response.Carbohydrate Polymers,205,192-202. |
| MLA | Zhang, Shulei,et al."Effective cancer immunotherapy by Ganoderma lucidum polysaccharide-gold nanocomposites through dendritic cell activation and memory T cell response".Carbohydrate Polymers 205(2019):192-202. |
入库方式： OAI收割
来源：上海药物研究所
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