Effect of Self-assembled Tween 20-SDS Nanometric Mixed Micelles Loaded with Probucol on Improvement of Oral Absorption
文献类型：期刊论文
| 作者 | Wang Yixin2; Jiang Shijun3; Huang Jian3; Wang Lingjiao1; Sun Guoxiang2 |
| 刊名 | Chinese Journal of Pharmaceuticals
 |
| 出版日期 | 2013 |
| 卷号 | 44期号:6页码:571-575 |
| 关键词 | UPLC-UV probucol self-assembled nanometric mixed micelle UPLC-UV oral absorption |
| ISSN号 | 1001-8255 |
| 其他题名 | 自组装Tween 20-SDS纳米混合胶束提高普罗布考口服吸收的研究 |
| 文献子类 | Article |
| 英文摘要 | Amphiphilic Tween-20 and sodium dodecyl sulfate (SDS) were mixed with probucol to prepare the nanometric mixed micelles with nuclear-shell structure by a self-assembly technique, in which probucol concentration could reach 20 mg/ml. The average particle size was (44.61.6)nm with PDI of 0.1790.058, which had no significant changes after diluted by agents of different pH. The effects of the product on skeleton proteins of Caco-2 cells was observed using laser confocal scan microscopy technique, and the results showed that the product could affect the skeleton proteins and enhance the mobility of cell membrane. An UPLC-UV method was established to measure probucol concentration in biological samples. The results of uptake with Caco-2 cell monolayer model and pharmacokinetics in rats showed that the product could significantly improve the oral absorption of slightly soluble probucol. |
| 资助项目 | 国家重大科学研究计划[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4879577 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267770]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China. 2.School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.; 3.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; |
| 推荐引用方式 GB/T 7714 | Wang Yixin,Jiang Shijun,Huang Jian,et al. Effect of Self-assembled Tween 20-SDS Nanometric Mixed Micelles Loaded with Probucol on Improvement of Oral Absorption[J]. Chinese Journal of Pharmaceuticals,2013,44(6):571-575. |
| APA | Wang Yixin,Jiang Shijun,Huang Jian,Wang Lingjiao,&Sun Guoxiang.(2013).Effect of Self-assembled Tween 20-SDS Nanometric Mixed Micelles Loaded with Probucol on Improvement of Oral Absorption.Chinese Journal of Pharmaceuticals,44(6),571-575. |
| MLA | Wang Yixin,et al."Effect of Self-assembled Tween 20-SDS Nanometric Mixed Micelles Loaded with Probucol on Improvement of Oral Absorption".Chinese Journal of Pharmaceuticals 44.6(2013):571-575. |
入库方式： OAI收割
来源：上海药物研究所
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