Efficacy and Toxicity of 5-Fluorouracil in Colon Cancer Treatment of a Mouse Syngeneic Model
文献类型：期刊论文
| 作者 | Tang Xuelian2; Fu Jinghua2; Park Hyun4; Yang Xinying1 |
| 刊名 | Journal of South China Agricultural University
 |
| 出版日期 | 2012 |
| 卷号 | 33期号:4页码:535-538 |
| 关键词 | 5-fluorouracil efficacy toxicity colon cancer |
| ISSN号 | 1001-411X |
| 其他题名 | 5-氟尿嘧啶在小鼠结肠癌模型中的药效与毒性评价研究 |
| 文献子类 | Article |
| 英文摘要 | To investigate the relationship of anticancer effects,toxicity and dose,tumor syngeneic models were made from murine colorectal adenocarcinoma cell line CT26 derived from BALB /c mice. Mice were treated with various doses (10,20,30 and 50 mg /kg) of 5-fluorouracil (5-FU),and the indexes were analyzed,including the anti-tumorigenic effects,body mass and mortality of mice.The results showed that the efficacy and toxicity of 5-FU was closely related to the doses,and the proposal dose was 20 - 30 mg /kg which may be the optimal dose for drug research in tumor syngeneic model of mice. |
| 资助项目 | The Public Welfare & Safety Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,Science and Technology[00000000] ; 国家自然科学基金[00000000] |
| WOS研究方向 | Oncology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4675095 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267814]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. 2.College of Animal Science,South China Agricultural University, Guangzhou, Guangdong 510642, China.; 3.韩国圆光大学医学院, 全罗北道, 570749, Korea.; 4.School of Medicine,Wonkwang University, Cholla-bukdo, 570749, South Korea.; |
| 推荐引用方式 GB/T 7714 | Tang Xuelian,Fu Jinghua,Park Hyun,et al. Efficacy and Toxicity of 5-Fluorouracil in Colon Cancer Treatment of a Mouse Syngeneic Model[J]. Journal of South China Agricultural University,2012,33(4):535-538. |
| APA | Tang Xuelian,Fu Jinghua,Park Hyun,&Yang Xinying.(2012).Efficacy and Toxicity of 5-Fluorouracil in Colon Cancer Treatment of a Mouse Syngeneic Model.Journal of South China Agricultural University,33(4),535-538. |
| MLA | Tang Xuelian,et al."Efficacy and Toxicity of 5-Fluorouracil in Colon Cancer Treatment of a Mouse Syngeneic Model".Journal of South China Agricultural University 33.4(2012):535-538. |
入库方式： OAI收割
来源：上海药物研究所
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