Effects on monomers of pentaeyclic triterpennoids of saikosaponines from Buplerum kunmingense against tetracycline-resistant Ureaplasma urealyticum
文献类型：期刊论文
| 作者 | Xu Qian1; Shen Liangliang1; Ye Yuankang1; Pan Shengli2; Wu Jimin3 |
| 刊名 | Chinese Journal of New Drugs and Clinical Remedies
 |
| 出版日期 | 2012 |
| 卷号 | 31期号:6页码:341-344 |
| 关键词 | Buplerum kunmingense Ureaplasma urealyticum tetracycline microbial sensitivity tests in vitro antibacterial activity |
| ISSN号 | 1007-7669 |
| 其他题名 | 五环三萜类柴胡皂苷单体对解脲脲原体四环素耐药株的作用 |
| 文献子类 | Article |
| 英文摘要 | AIM To isolate monomers of pentaeyclic triterpennoids of saikosaponins from Bupleurum kunmingense and to study the antimicrobial activity of monomer Bp3 against tetracycline-resistant Ureaplasma urealyticum and the interaction with tetracycline.METHODS According to the standard of Clinical and Laboratory Standards Institute,the effects of respective or combined Bp3 and tetracycline on 20 strains of tetracycline-resistant Ureaplasma urealyticum were studied by the checkerboard microdilution method.The interaction of Bp3 and tetracycline were studied by fractional inhibitory concentration(FIC).RESULTS When Bp3 and tetracycline were given separately,the geometric mean(MG)of minimal inhibitory concentration(MIC)were 1.234 mg·L~(-1) and 0.948 mg·L~(-1) respectively.When they were given combined,the MG of Bp3 and tetracycline reduced to 0.692 mg·L~(-1) and 0.271 mg·L~(-1) respectively.There were significant differences between MIC of separation and MIC of combination(P < 0.05),and the interaction analysis showed synergistic or additive effects in the 20 tetracycline-resistant strains.CONCLUSION The monomer Bp3 of pentaeyclic triterpennoids of saikosaponines from Buplerum kunmingense has an inhibitory effect on tetracycline-resistant Ureaplasma urealyticum and has synergistic and additive effects with tetracycline. |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4581025 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267829]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Department of Dermatology,Tongji Hospital,Tongji University, SHANGHAI 200065, China.; 2.School of Pharmacy,Fudan University, SHANGHAI 200232, China.; 3.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, SHANGHAI 201203, China. |
| 推荐引用方式 GB/T 7714 | Xu Qian,Shen Liangliang,Ye Yuankang,et al. Effects on monomers of pentaeyclic triterpennoids of saikosaponines from Buplerum kunmingense against tetracycline-resistant Ureaplasma urealyticum[J]. Chinese Journal of New Drugs and Clinical Remedies,2012,31(6):341-344. |
| APA | Xu Qian,Shen Liangliang,Ye Yuankang,Pan Shengli,&Wu Jimin.(2012).Effects on monomers of pentaeyclic triterpennoids of saikosaponines from Buplerum kunmingense against tetracycline-resistant Ureaplasma urealyticum.Chinese Journal of New Drugs and Clinical Remedies,31(6),341-344. |
| MLA | Xu Qian,et al."Effects on monomers of pentaeyclic triterpennoids of saikosaponines from Buplerum kunmingense against tetracycline-resistant Ureaplasma urealyticum".Chinese Journal of New Drugs and Clinical Remedies 31.6(2012):341-344. |
入库方式： OAI收割
来源：上海药物研究所
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