Design,synthesis and bioactivity of aryl piperazine benzo[b]oxazine derivatives
文献类型：期刊论文
| 作者 | Zheng Yongyong2; Xie Peng2; Zhang Jin2; Li Jianqi2; Guo Lin1; Yu Leiping1; Zhou Bin2 |
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2012 |
| 卷号 | 47期号:6页码:755-763 |
| 关键词 | 5-HT_(1A) aryl piperazine benzo [b] oxazine derivatives pharmacophore model 5-HT reuptake 5-HT_(1A) |
| ISSN号 | 0513-4870 |
| 其他题名 | 芳基哌嗪苯并噁嗪类化合物的设计、合成及生物活性研究 |
| 文献子类 | Article |
| 英文摘要 | Compounds with serotonin reuptake inhibition/5-HT_(1A) dual activity were used to build 3D pharmacophore model as a training molecules by Discover Studio.Based on the model,8 novel aryl piperazine benzo [b] oxazine derivatives were designed and synthesized,and their structures were confirmed by ~1H NMR and HR-MS.Biological evaluation illustrated that compounds VI_1 and VI_7 showed potent functional activities at both 5-HT transporter and 5-HT_(1A) receptor,which can be used as lead compounds to guide future research of design and synthesis of potent novel compounds. |
| 资助项目 | 国家自然科学基金资助项目[00000000] ; 国家重大新药创制科技重大专项资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4550467 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267841]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. 2.Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China.; |
| 推荐引用方式 GB/T 7714 | Zheng Yongyong,Xie Peng,Zhang Jin,et al. Design,synthesis and bioactivity of aryl piperazine benzo[b]oxazine derivatives[J]. Acta Pharmaceutica Sinica,2012,47(6):755-763. |
| APA | Zheng Yongyong.,Xie Peng.,Zhang Jin.,Li Jianqi.,Guo Lin.,...&Zhou Bin.(2012).Design,synthesis and bioactivity of aryl piperazine benzo[b]oxazine derivatives.Acta Pharmaceutica Sinica,47(6),755-763. |
| MLA | Zheng Yongyong,et al."Design,synthesis and bioactivity of aryl piperazine benzo[b]oxazine derivatives".Acta Pharmaceutica Sinica 47.6(2012):755-763. |
入库方式： OAI收割
来源：上海药物研究所
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