Structural modification of the cape jasmine pharmacodynamic constituent genipin
文献类型：期刊论文
| 作者 | HUANG Zhao; LUO Jun; CHEN Heru; YAO Xinsheng |
| 刊名 | Chinese Journal of Medicinal Chemistry
 |
| 出版日期 | 2011 |
| 卷号 | 21期号:3页码:204-207 |
| 关键词 | genipin Alzheimer′s disease cape jasmine structural modification |
| ISSN号 | 1005-0108 |
| 其他题名 | 栀子药效成分京尼平的结构改造 |
| 文献子类 | Article |
| 英文摘要 | The pharmacological action on Alzheimer′s disease of genipin has long been proved.In order to disclose the pharmacophore,structural modification of genipin was pursued in the current paper.The structural modifications included the employment of Swern reaction to turn semiacetal at position 1 into lactone,as well as hydroxyl group at position 10 into aldehyde.Selective hydrogenation was used to reduce the double bond at position 7 and 8.The yield for each step lies among 77% to 90%.All the compounds synthesized here were identified with 1H-NMR,13C-NMR and MS. |
| 资助项目 | 新药研究国家重点实验室开放课题[00000000] ; 广东省科技计划项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4228001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267881]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | Institute of Traditional Chinese Medicine and Natural Product College of Pharmacy Ji′nan University, Guangzhou, Guangdong 510632, China. |
| 推荐引用方式 GB/T 7714 | HUANG Zhao,LUO Jun,CHEN Heru,et al. Structural modification of the cape jasmine pharmacodynamic constituent genipin[J]. Chinese Journal of Medicinal Chemistry,2011,21(3):204-207. |
| APA | HUANG Zhao,LUO Jun,CHEN Heru,&YAO Xinsheng.(2011).Structural modification of the cape jasmine pharmacodynamic constituent genipin.Chinese Journal of Medicinal Chemistry,21(3),204-207. |
| MLA | HUANG Zhao,et al."Structural modification of the cape jasmine pharmacodynamic constituent genipin".Chinese Journal of Medicinal Chemistry 21.3(2011):204-207. |
入库方式： OAI收割
来源：上海药物研究所
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