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Analysis on pharmacokinetics-pharmacodynamics correlation of Huanglian Jiedu Decoction
文献类型：期刊论文
| 作者 | Song Jue3; Lu Tong1; Xie Lin2; Liu Xiaodong2 |
| 刊名 | Chinese Traditional and Herbal Drugs
 |
| 出版日期 | 2011 |
| 卷号 | 42期号:10页码:2042-2046 |
| 关键词 | Huanglian Jiedu Decoction(HJD) Scutellariae Radix baicalin wogonoside pharmacokinetics(PK) pharmacodynamics(PD) |
| ISSN号 | 0253-2670 |
| 其他题名 | 黄连解毒汤的药动学-药效学相关性研究 |
| 文献子类 | Article |
| 英文摘要 | Objective To study pharmacokinetics-pharmacodynamics(PK-PD) correlation of Huanglian Jiedu Decoction(HJD) through simultaneous determination of baicalin and wogonoside in serum after oral administration of HJD,Scutellariae Radix extract,and baicalin to rats.Methods The serum concentrations of baicalin and wogonoside were simultaneously detected with an HPLC method and the area under serum concentration-time curve(AUC) was calculated.The correlation between the parameter area under serum effect-time curve(AUE) and AUC was analyzed.Results The scatterplots of lg(AUC)-AUE in above three groups were formed as "S-shaped" curves.Conclusion The anti-oxidative effects of HJD,Scutellariae Radix extract,and baicalin have a positive correlation with baicalin and wogonoside levels in serum.Baicalin may act as one of the anti-oxidants both in Scutellariae Radix extract and HJD.Also,wogonoside has anti-oxidative effects to some extent. |
| 资助项目 | 安徽省高等学校青年教师科研资助计划[00000000] ; 安徽医科大学校科研基金[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4365319 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267906]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.DMPK Center,Shanghai Institute of Materia Medica,Chinese Academy of Science, Shanghai 201203, China.; 2.Key Laboratory of Drug Metabolism & Pharmacokinetics,China Pharmaceutical University, Nanjing, Jiangsu 210038, China. 3.College of Pharmacy,Anhui Medical University, Hefei, Anhui 230032, China.; |
| 推荐引用方式 GB/T 7714 | Song Jue,Lu Tong,Xie Lin,et al. Analysis on pharmacokinetics-pharmacodynamics correlation of Huanglian Jiedu Decoction[J]. Chinese Traditional and Herbal Drugs,2011,42(10):2042-2046. |
| APA | Song Jue,Lu Tong,Xie Lin,&Liu Xiaodong.(2011).Analysis on pharmacokinetics-pharmacodynamics correlation of Huanglian Jiedu Decoction.Chinese Traditional and Herbal Drugs,42(10),2042-2046. |
| MLA | Song Jue,et al."Analysis on pharmacokinetics-pharmacodynamics correlation of Huanglian Jiedu Decoction".Chinese Traditional and Herbal Drugs 42.10(2011):2042-2046. |
入库方式： OAI收割
来源：上海药物研究所
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