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Design,synthesis and monoamine reuptake inhibitors activities of 4-aminopiperidine derivatives

文献类型：期刊论文

作者Zheng Yongyong2; Yu Leiping1; Guo Lin1; Li Jianqi2
刊名Chinese Journal of Medicinal Chemistry
出版日期2010
卷号20期号:6页码:476-483
关键词4-aminopiperidine monoamine reuptake inhibitor synthesis
ISSN号1005-0108
其他题名4-氨基哌啶类化合物的设计,合成及其对单胺递质再摄取的抑制活性
文献子类Article
英文摘要Aim To design and synthesize 4-aminopiperidine derivatives monoamine reuptake inhibitors.Methods The target compounds Ⅰ1-Ⅰ9 were prepared by N-alkylation of 4-aminopiperidine derivatives,and compounds Ⅰ10-Ⅰ17 were obtained by reduction of compounds Ⅰ1-Ⅰ9 with NaBH4.Results and conclusion Seventeen new target compounds were synthesized and their structures were confirmed by HR-MS and 1H-NMR.The results of preliminary pharmacological test showed that five of seventeen compounds possessed diverse monoamine reuptake inhibitors activities
资助项目国家自然科学基金项目[00000000] ; 国家十一五"重大新药创制"项目[00000000]
WOS研究方向Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:4093002
源URL[http://119.78.100.183/handle/2S10ELR8/267938]  
专题中国科学院上海药物研究所
作者单位1.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China.
2.Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China.;
推荐引用方式
GB/T 7714		 Zheng Yongyong,Yu Leiping,Guo Lin,et al. Design,synthesis and monoamine reuptake inhibitors activities of 4-aminopiperidine derivatives[J]. Chinese Journal of Medicinal Chemistry,2010,20(6):476-483.
APA Zheng Yongyong,Yu Leiping,Guo Lin,&Li Jianqi.(2010).Design,synthesis and monoamine reuptake inhibitors activities of 4-aminopiperidine derivatives.Chinese Journal of Medicinal Chemistry,20(6),476-483.
MLA Zheng Yongyong,et al."Design,synthesis and monoamine reuptake inhibitors activities of 4-aminopiperidine derivatives".Chinese Journal of Medicinal Chemistry 20.6(2010):476-483.

入库方式： OAI收割

来源：上海药物研究所

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