Metabolites of Notoginsenoside R_1 in Rats
文献类型：期刊论文
| 作者 | CHEN Guang-tong2; YANG Min1 |
| 刊名 | Lishizhen Medicine and Materia Medica Research
 |
| 出版日期 | 2010 |
| 卷号 | 21期号:2页码:485-487 |
| 关键词 | Notoginsenoside R_1 Metabolites LC-MS/MS |
| ISSN号 | 1008-0805 |
| 其他题名 | 三七皂苷R_1在大鼠体内的代谢产物分析 |
| 文献子类 | Article |
| 英文摘要 | Objective To investigate the metabolites of notoginsenoside R1 in rats. Methods The microbial transformation metabolites of notoginsenoside R_1 were used as standard references. LC-ESI-MS/MS analysis was used in the metabolism studies of notoginsenoside R_1 in rats. Results The structures of eight metabolites of notoginsenoside R_1 in rat feces were identified by comparison with the reference standards separated from biotransformation. Their structures were identified as 20(S)-notoginsenoside R_2, 20(R)-notoginsenoside R_2, 20(S)-ginsenoside Rh_1, 20(R)-ginsenoside Rh_1, ginsenoside Rh_4, protopanaxatriol, ginsenoside F_1 and 3beta, 12beta-dihydroxydammar-E-20(22)-24- diene-6-O-beta-D-xylopyranosyl-(12)-beta-D-glucopyranoside.Conclusion Notoginsenoside R_1 is extensively metabolized in rat and has the same metabolic pathway with microorganisms to some extent. |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3835472 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267949]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. 2.Nantong University, Nantong, Jiangsu 226001, China.; |
| 推荐引用方式 GB/T 7714 | CHEN Guang-tong,YANG Min. Metabolites of Notoginsenoside R_1 in Rats[J]. Lishizhen Medicine and Materia Medica Research,2010,21(2):485-487. |
| APA | CHEN Guang-tong,&YANG Min.(2010).Metabolites of Notoginsenoside R_1 in Rats.Lishizhen Medicine and Materia Medica Research,21(2),485-487. |
| MLA | CHEN Guang-tong,et al."Metabolites of Notoginsenoside R_1 in Rats".Lishizhen Medicine and Materia Medica Research 21.2(2010):485-487. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。