In vitro antitumor activity and synthesis of the key intermediate of bakuchiol
文献类型：期刊论文
| 作者 | CHEN Hong-li; FENG Hui-jin ; LI Yuan-chao
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2010 |
| 卷号 | 45期号:4页码:467-470 |
| 关键词 | bakuchiol antitumor activity Ireland-Claisen rearrangement synthesis |
| ISSN号 | 0513-4870 |
| 其他题名 | 补骨脂酚的体外抗肿瘤活性及其关键中间体的合成研究 |
| 文献子类 | Article |
| 英文摘要 | The in vitro antitumor activity of bakuchiol was exploited.compared with tamoxifen.The result of biological activities showed that bakuchiol could inhibit human breast cancer and the IC_(50) values were 2.89*10~(-5)mol·L~(-1)and 8.29*10~(-3) mol·L~(-1) against the cells line T-47D and MDA-MB-231 respectively. On the other hand.the key intermediate to synthesize bakuchiol was obtained by the method of Ireland-Claisen rearrangement.Comparing with traditional Claisen rearrangement，the reaction conditions are milder and the reaction reagents are safer. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3863665 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267965]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | Shanghai lnstitute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | CHEN Hong-li,FENG Hui-jin,LI Yuan-chao. In vitro antitumor activity and synthesis of the key intermediate of bakuchiol[J]. Acta Pharmaceutica Sinica,2010,45(4):467-470. |
| APA | CHEN Hong-li,FENG Hui-jin,&LI Yuan-chao.(2010).In vitro antitumor activity and synthesis of the key intermediate of bakuchiol.Acta Pharmaceutica Sinica,45(4),467-470. |
| MLA | CHEN Hong-li,et al."In vitro antitumor activity and synthesis of the key intermediate of bakuchiol".Acta Pharmaceutica Sinica 45.4(2010):467-470. |
入库方式： OAI收割
来源：上海药物研究所
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