Design and synthesis of nitrogen-containing benzoheterocyclic derivatives and their antipsychotic activities
文献类型：期刊论文
| 作者 | PENG Shao-ping2; YU Lei-ping1; LI Jian-qi2 |
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2009 |
| 卷号 | 44期号:9页码:994-1001 |
| 关键词 | antipsychotics partial agonist synthesis |
| ISSN号 | 0513-4870 |
| 其他题名 | 3,4-2[1H]-二氢喹啉酮衍生物的设计合成及抗精神分裂症活性研究 |
| 文献子类 | Article |
| 英文摘要 | A series of nitrogen-containing benzoheterocyclic derivatives were synthesized and tested for their antipsychotic activities.Their structures were confirmed by ~1H NMR and HR-MS.Preliminary in vitro pharmacological trials showed that most of the target compounds have high affinity with D_2 and 5-HT_(2A) receptors.Among the tested compounds,20 exhibited the highest affinity and D_2 partial agonist activity.In vivo studies showed 20 has potent antipsychotic activities on apomorphine mice model,which is a chance to find a better precursor of D_2 partial agonist for further optimization. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3698469 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268025]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. 2.Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China.; |
| 推荐引用方式 GB/T 7714 | PENG Shao-ping,YU Lei-ping,LI Jian-qi. Design and synthesis of nitrogen-containing benzoheterocyclic derivatives and their antipsychotic activities[J]. Acta Pharmaceutica Sinica,2009,44(9):994-1001. |
| APA | PENG Shao-ping,YU Lei-ping,&LI Jian-qi.(2009).Design and synthesis of nitrogen-containing benzoheterocyclic derivatives and their antipsychotic activities.Acta Pharmaceutica Sinica,44(9),994-1001. |
| MLA | PENG Shao-ping,et al."Design and synthesis of nitrogen-containing benzoheterocyclic derivatives and their antipsychotic activities".Acta Pharmaceutica Sinica 44.9(2009):994-1001. |
入库方式： OAI收割
来源：上海药物研究所
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