The potentiation of antimalarial activities by daphnetin derivatives against malaria parasites in vitro and in vivo
文献类型：期刊论文
| 作者 | HUANG Fang1; TANG Linhua1; YU Linqian2; NI Yichang1; WANG Qinmei1; ZHOU Shuisen1 |
| 刊名 | Journal of Pathogen Biology
 |
| 出版日期 | 2008 |
| 卷号 | 3期号:1页码:35-38 |
| 关键词 | Daphnetin antimalarial drugs screening Plasmodium fah＇iparum Plasmodium berghei |
| ISSN号 | 1673-5234 |
| 其他题名 | 瑞香素结构衍生物体内外抗疟活性的研究 |
| 文献子类 | Article |
| 英文摘要 | Objective To screen antimalarial activities of daphnetin derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo. Methods The antimalarial activities of daphnetin derivatives against P. falciparum in vitro were screened by microscopy-based assay and microfluorimetric method. The schizontocidal effect of daphnetin derivatives with potent antimalarial activity in vivo assay were tested in mice infected with P. beighei ANKA according to the ＂4-day suppress assay＂ recommended by WHO. Results DA78 and DA79 showed potent antimalarial activities against P. falciparum in vitro at the same level of daphnetin. The IC_(50) values of DA78 and DA79 were 7.6mumol/L and 1.4 mumol/L, respectively. The in vivo antimalarial effects of DA78 and DA79 was assessed by reduction rate of parasitemia on day 4. The reduction rate of parasitemia on D4 treated with 1,10,50,75 mg/kg·d*4 d DA79 intragastrically whereas control group had significant difference （P〈0.01）, and the reduction rate of parasitemia on D4 treated with 50 or 75 mg/kg· d*4 d DA78 intragastrically whereas control group had significant difference （P〈0.05）. The antimalarial efficacy of DA79 10 or 75 mg/kg·d*4 d were better than the same dosage of daphnetin. Conclusion As new antimalarial compounds, daphnetin derivatives DA78 and DA79 Showed antimalarial activity in vitro and in vivo, which might provide a new direction to discovery of more effective antimalarial compounds and have laid a basis for further research and development of daphnetin derivatives antimalarial drugs. |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3203619 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268052]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai 200025, China.; 2.Chinese National Center for Drug Screening, Shanghai Institute of Materia Medica, Graduate School of the Chinese Academy of Sciences, Shanghai 200025, China. |
| 推荐引用方式 GB/T 7714 | HUANG Fang,TANG Linhua,YU Linqian,et al. The potentiation of antimalarial activities by daphnetin derivatives against malaria parasites in vitro and in vivo[J]. Journal of Pathogen Biology,2008,3(1):35-38. |
| APA | HUANG Fang,TANG Linhua,YU Linqian,NI Yichang,WANG Qinmei,&ZHOU Shuisen.(2008).The potentiation of antimalarial activities by daphnetin derivatives against malaria parasites in vitro and in vivo.Journal of Pathogen Biology,3(1),35-38. |
| MLA | HUANG Fang,et al."The potentiation of antimalarial activities by daphnetin derivatives against malaria parasites in vitro and in vivo".Journal of Pathogen Biology 3.1(2008):35-38. |
入库方式： OAI收割
来源：上海药物研究所
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