Isolation and Identification of Impurities in Spironolactone
文献类型：期刊论文
| 作者 | ZHAO Lian3; CHEN Hua3; WANG Youfu1; LI Yuanchao2 |
| 刊名 | Chinese Pharmaceutical Journal
 |
| 出版日期 | 2008 |
| 卷号 | 43期号:3页码:230 |
| 关键词 | spironolactone 7alpha-acetyhhio-17beta-methoxy-pregn-4-en-3-one |
| ISSN号 | 1001-2494 |
| 其他题名 | 螺内酯杂质的分离与结构鉴定 |
| 文献子类 | Article |
| 英文摘要 | OBJECTIVE To study the impurity of spironolactone. METHODS The chemical constituents were separated by chromatography. The structure was determined by NMR and MS spectral analysis. RESULTS Two spironalactone-analogs were isolated and identified as 7alpha-acetylthio-17beta-methoxy-pregn-4-en-3-one （2） and 17beta-hydroxy-3-oxopregna-4-ene-21- carboxylic acid y-lactone （3）. CONCLUSION Compound 2 was a new compound. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3233672 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268058]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Zhejiang Xianju Second Pharmaceutic Factory, Xianju, 317300.; 2.Shanghai lnstitute of Materia Medica , Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China. 3.College of Chemistry and Environment Sciences,HeBei University, Baoding, Hebei 071002, China.; |
| 推荐引用方式 GB/T 7714 | ZHAO Lian,CHEN Hua,WANG Youfu,et al. Isolation and Identification of Impurities in Spironolactone[J]. Chinese Pharmaceutical Journal,2008,43(3):230. |
| APA | ZHAO Lian,CHEN Hua,WANG Youfu,&LI Yuanchao.(2008).Isolation and Identification of Impurities in Spironolactone.Chinese Pharmaceutical Journal,43(3),230. |
| MLA | ZHAO Lian,et al."Isolation and Identification of Impurities in Spironolactone".Chinese Pharmaceutical Journal 43.3(2008):230. |
入库方式： OAI收割
来源：上海药物研究所
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