Preparation and in vitro corneal retention behavior of novel cationic microemulsion/in situ gel system
文献类型：期刊论文
| 作者 | MA Shouwei1; GAN Yong3 ; GAN Li3; ZHU Chunliu3; Zhu Jiabi1
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2008 |
| 卷号 | 43期号:7页码:749-755 |
| 关键词 | vitamin A palmitate cationic microemulsion in situ gel ocular retention rheology |
| ISSN号 | 0513-4870 |
| 其他题名 | 新型眼用阳离子微乳-原位凝胶的制备及其体外角膜滞留特性的研究 |
| 文献子类 | Article |
| 英文摘要 | The aim was to prepare a novel ocular cationic microemulsion-in situ gel(CM-ISG) system with vitamin A palmitate (VAP) as model drug,and investigate the corneal retention behavior and corneal irritation of the system.VAP/CM was prepared by a process based on supply of energy,and the before-and-after gelation rheology of VAP/CM-ISG was investigated.In vitro VAP release and gel dissolution of both VAP/CM-ISG and Oculotect Gel was determined.And in vitro corneal retention behavior of both formulations was evaluated by captive bubble technique.Ocular irritation test was carried out based on the Draize method.Images of TEM showed that homogenous VAP/CM was made,and no significant differences of particle size were found between the VAP/CM and VAP/CM in Poloxamer 407 gel.Rheology study illustrated that VAP/CM reduced the phase transition temperature of Poloxamer 407 gel by 1.5 ℃,and the elastic modulus increased about 15.7 times.The in vitro release and gel dissolution profile of both formulations exhibited the characteristics of zero order kinetics.Comparing with Oculotect Gel,desorption kinetics study of VAP/CM-ISG exhibited longer corneal retention time and smaller contact angle.Irritation test showed a good ocular compatibility of VAP/CM-ISG.Therefore,VAP/CM-ISG combined both advantages of the cationic microemulsion and in situ gel system,provided better wettability and longer ocular retention time.It might be a promising ocular drug delivery system. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3336145 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268095]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.China Pharmaceutical University, Nanjing, Jiangsu 210009, China.; 2.Shanghai 201203, China. 3.Institute of Materia; |
| 推荐引用方式 GB/T 7714 | MA Shouwei,GAN Yong,GAN Li,et al. Preparation and in vitro corneal retention behavior of novel cationic microemulsion/in situ gel system[J]. Acta Pharmaceutica Sinica,2008,43(7):749-755. |
| APA | MA Shouwei,GAN Yong,GAN Li,ZHU Chunliu,&Zhu Jiabi.(2008).Preparation and in vitro corneal retention behavior of novel cationic microemulsion/in situ gel system.Acta Pharmaceutica Sinica,43(7),749-755. |
| MLA | MA Shouwei,et al."Preparation and in vitro corneal retention behavior of novel cationic microemulsion/in situ gel system".Acta Pharmaceutica Sinica 43.7(2008):749-755. |
入库方式： OAI收割
来源：上海药物研究所
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