Total synthesis of quinolizidine alkaloids(-)-lasubine Ⅱ
文献类型：期刊论文
| 作者 | LIU Shengyang2; HUA Weiyi2; HAJI Akberb4; LIAO Lixin4; WANG Wei1 |
| 刊名 | Journal of China Pharmaceutical University
 |
| 出版日期 | 2007 |
| 卷号 | 38期号:3页码:193-198 |
| 关键词 | lasubine lasubine quinolizidine ring-closing metathesis Roush allylborations |
| ISSN号 | 1000-5048 |
| 其他题名 | 喹诺里西啶类生物碱(-)-lasubineⅡ的全合成 |
| 文献子类 | Article |
| 英文摘要 | Aim: To study and improve enantioselective total synthesis of quinolizidine alkaloid(-)-lasubine Ⅱ. Methods: A new approach to total synthesis of (-)-lasubine Ⅱ was established from readily available starting materials, via the new synthetic sequence including the creation of stereogenic centers through two sequential highly stereoselective Roush allylborations, S_N2 cyclization and ring-closing metathesis reactions for the construction of the lasubine′s quinolizidine skeleton. Results and Conclusion: The synthesis of natural product(-)-lasubine Ⅱ has been accomplished by a new synthetic route in an overall yield of 15. 3% and its spectrum data, including ~1H NMR, ~(13)C NMR, EI-MS, IR and optical rotation, is in agreement with the literature data. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2817039 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268131]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Department of Chemistry, University of New Mexico,, Albuquerque, NM 87131-0001, USA. 2.Department of Medicinal Chemistry; 3.Nanjing, Jiangsu 210009, China.; 4.Shanghai Institute of Materia Medica; 5.Shanghai 201203, China.; |
| 推荐引用方式 GB/T 7714 | LIU Shengyang,HUA Weiyi,HAJI Akberb,et al. Total synthesis of quinolizidine alkaloids(-)-lasubine Ⅱ[J]. Journal of China Pharmaceutical University,2007,38(3):193-198. |
| APA | LIU Shengyang,HUA Weiyi,HAJI Akberb,LIAO Lixin,&WANG Wei.(2007).Total synthesis of quinolizidine alkaloids(-)-lasubine Ⅱ.Journal of China Pharmaceutical University,38(3),193-198. |
| MLA | LIU Shengyang,et al."Total synthesis of quinolizidine alkaloids(-)-lasubine Ⅱ".Journal of China Pharmaceutical University 38.3(2007):193-198. |
入库方式： OAI收割
来源：上海药物研究所
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