Effects of unilateral sciatic neurectomy in rat on bone mineral density of femur and tibia
文献类型：期刊论文
| 作者 | YAN Xueming; FUKUDA Satoshi |
| 刊名 | Chinese Journal of Osteoporosis
 |
| 出版日期 | 2007 |
| 卷号 | 13期号:9页码:624-626 |
| 关键词 | pQCT pQCT Bone mineral density（BMD） Tibia Femur Rat |
| ISSN号 | 1006-7108 |
| 其他题名 | 大鼠坐骨神经切断对后肢骨密度的影响 |
| 文献子类 | Article |
| 英文摘要 | Objective To determine the effects of unilateral sciatic neurectomy （USN） on hind leg bone mineral density （BMD）, BMD were measured by a peripheral quantitative computed tomography （pQCT）, and the correlation data were analyzed, which will provide the reference for the research on disused osteoporosis. Methods SD rats （2 months, female） were used, and divided into two groups. USN-operated and sham-operated, and performed under anesthesia. Body weight was scaled weekly, and the rats were sacrificed after 6 weeks. BMD on femur and tibia were measured by pQCT at 3.0 and 12.0 mm from the proximal epiphysis. Results For both USN- operated and sham-operated group, except 1^st week, the increasing rate for the body weight of rat was similar to that of age growth ; The leg＇ muscular atrophy with paralysis showed significantly, and total BMD of femur and tibia markedly decreased in USN-operated group. The BMD of right hind leg is obviously different from that of left hind leg in cancellous bone （ P 〈 0.01 ）. Conclusions The pQCT can sensibly discern various regions of skeletal changes 6 weeks after unilateral sciatic neurectomy. |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2930313 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268132]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | Shanghai Institute of Materia Medico, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | YAN Xueming,FUKUDA Satoshi. Effects of unilateral sciatic neurectomy in rat on bone mineral density of femur and tibia[J]. Chinese Journal of Osteoporosis,2007,13(9):624-626. |
| APA | YAN Xueming,&FUKUDA Satoshi.(2007).Effects of unilateral sciatic neurectomy in rat on bone mineral density of femur and tibia.Chinese Journal of Osteoporosis,13(9),624-626. |
| MLA | YAN Xueming,et al."Effects of unilateral sciatic neurectomy in rat on bone mineral density of femur and tibia".Chinese Journal of Osteoporosis 13.9(2007):624-626. |
入库方式： OAI收割
来源：上海药物研究所
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