Effects of Rhodojaponin Ⅲ on Contractile Force of Papillary Muscles and Ion Currents in Ventricular Myocytes of Guinea Pigs
文献类型：期刊论文
| 作者 | Liu Hui; Hu Zhuangli; Zhang Deyong |
| 刊名 | Journal of Huazhong University of Science and Technology
 |
| 出版日期 | 2007 |
| 卷号 | 36期号:2页码:162 |
| 关键词 | rhodojaponin Ⅲ myocardium contractile force sodium channel calcium channel |
| ISSN号 | 1672-0741 |
| 其他题名 | 闹羊花毒素Ⅲ对豚鼠心室乳头肌收缩力和离子流的作用 |
| 文献子类 | Article |
| 英文摘要 | Objective To investigate the effects of rhodojaponin Ⅲ （RH-Ⅲ） on contractile force of papillary muscles, sodium current （INa）, calcium current （Ica） and Na^＋ -Ca^2＋ exchange current （I（Na-Ca）） in ventricular myocytes of guinea pigs. Methods Contractility of myocardium was studied with isolated papillary muscles and ion currents were measured by whole cell patch clamp configuration. Results ①RH-Ⅲ （ 0.1, 0.3 and 1.0 mumol/L） produced positive inotropic effects on the papillary muscles in a dose-dependent manner. The contractile force was increased by （27.0 8. 2） %, （56.0 16. 6）% and （102.0 38.4）% （n=6, P〈0. 01 ）, respectively. At higher concentrations, RH-Ⅲ caused arrhythmias. 3.0mumol/L tetrodotoxin （TTX） abolished the positive inotropic effects and arrhythmias induced by RH-Ⅲ. QAt potential of ＋50 mV, 1.0mumol/L RH-Ⅲ increased the Ni^2＋ -sensitive I（Na-Ca） from （12330） pA to （23249） pA （n=5, P〈0.01 ）. ③1.0 mumol/L RH-Ⅲ decreased the peak amplitude of INa from （3.580. 86） nA to （1.300.38） nA （n=5, P〈0.01 ）, but RH-Ⅲ did not affect Ica [from （852260） pA to （818226） pA, n=5, P〉0. 05]. Conclusion The stimulatory effect of RH-Ⅲ on I（Na-Ca） contributes to its positive inotropic action in myoeardium of guinea pigs. |
| 资助项目 | 国家自然科学基金资助项目（No.30170104）[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2879810 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268137]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | Department of Pharmacology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. |
| 推荐引用方式 GB/T 7714 | Liu Hui,Hu Zhuangli,Zhang Deyong. Effects of Rhodojaponin Ⅲ on Contractile Force of Papillary Muscles and Ion Currents in Ventricular Myocytes of Guinea Pigs[J]. Journal of Huazhong University of Science and Technology,2007,36(2):162. |
| APA | Liu Hui,Hu Zhuangli,&Zhang Deyong.(2007).Effects of Rhodojaponin Ⅲ on Contractile Force of Papillary Muscles and Ion Currents in Ventricular Myocytes of Guinea Pigs.Journal of Huazhong University of Science and Technology,36(2),162. |
| MLA | Liu Hui,et al."Effects of Rhodojaponin Ⅲ on Contractile Force of Papillary Muscles and Ion Currents in Ventricular Myocytes of Guinea Pigs".Journal of Huazhong University of Science and Technology 36.2(2007):162. |
入库方式： OAI收割
来源：上海药物研究所
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