Antigout effect of renierol extracted from the marine sponge in the South China Sea
文献类型：期刊论文
| 作者 | SANG Yanjun2; GOU Yaowei1; HUANG Caiguo2; JIA Rui1; XU Qiangzhi2; WEI Shanjian2; JIAO Binhua2 |
| 刊名 | Chinese Journal of Marine Drugs
 |
| 出版日期 | 2006 |
| 卷号 | 25期号:5页码:25-27 |
| 关键词 | Haliclona sp Haliclona sp sponge xanthine oxidase |
| ISSN号 | 1002-3461 |
| 其他题名 | 中国南海海绵提取物-renierol抗痛风作用的实验研究 |
| 文献子类 | Article |
| 英文摘要 | Objective To investigate the inhibitive effect of renierol extracted from the marine sponge in the South China Sea on xanthine oxidase and the effect on mice hyperuricemia as well as its possible mechanisms. Methods Renierol was extracted from sponge and its antigoat effect was tested. The activity of xanthine oxidase was measured by using the generation of uric acid method and the NBT reduction induced by superoxide anions, then its possible mechanism was estimated. Results The two methods showed renierol could obviously inhibit the effect of xanthine oxidase with IC50of 1.85 and 1.36mug·mL^-1 , respectively. Conclusion Renierol extracted from the marine sponge can effectively inhibit the effect of xanthine oxidase. |
| WOS研究方向 | Zoology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2627998 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268193]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Shanghai Institute of Materia Medica, Shanghai 201203, China. 2.Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China.; |
| 推荐引用方式 GB/T 7714 | SANG Yanjun,GOU Yaowei,HUANG Caiguo,et al. Antigout effect of renierol extracted from the marine sponge in the South China Sea[J]. Chinese Journal of Marine Drugs,2006,25(5):25-27. |
| APA | SANG Yanjun.,GOU Yaowei.,HUANG Caiguo.,JIA Rui.,XU Qiangzhi.,...&JIAO Binhua.(2006).Antigout effect of renierol extracted from the marine sponge in the South China Sea.Chinese Journal of Marine Drugs,25(5),25-27. |
| MLA | SANG Yanjun,et al."Antigout effect of renierol extracted from the marine sponge in the South China Sea".Chinese Journal of Marine Drugs 25.5(2006):25-27. |
入库方式： OAI收割
来源：上海药物研究所
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