NEUROBIOLOGY OF PSYCHOSTIMULANT ADDICTION
文献类型：期刊论文
| 作者 | SHI Weixing |
| 刊名 | Chinese Journal of Drug Dependence
 |
| 出版日期 | 2006 |
| 卷号 | 15期号:3页码:168-172 |
| 关键词 | amphetamine - like psychostimulants dopamine transporter prefrontal cortex dopamine neuron firing pattern impulse - dependent release |
| ISSN号 | 1007-9718 |
| 其他题名 | 精神兴奋剂的强化作用和成瘾的神经生物学 |
| 文献子类 | Review |
| 英文摘要 | Amphetamine -like psychostimulants are thought to increase dopamine （DA） transmission by binding to DA transporters （DATs） to facilitate DA reverse transport and/or to block DA reuptake. In this article, we will review evidence from both our own studies and others that psychostimulants can also act through both DA - and non - DA - mediated mechanisms to powerfully influence the firing rate and pattern of DA neurons and thus impulse - dependent DA release. Evidence further suggests that DATs are not absolutely required for the reinforcing effects of psychostimulants, and that changes in impulse - dependent DA release may play a more critical role in behaviors associated with psychostimulant abuse. Based on these and other findings, we propose that the reinforcing effects of psychostimulants depend on both the amplitude and the temporal pattern of DA release induced by these drugs. The latter, determined by the firing pattern of DA neurons, may encode information from brain areas that project to DA neurons, including the prefrontal cortex and the nucleus accumbens. Further understanding of how DA neurons interact with these brain areas in space and time and how this interaction is altered by psychostimulants may shed new light on the neuronal mechanisms underlying psychostimulant addiction. |
| 资助项目 | 国家重点基础研究发展计划（973计划）[00000000] ; 国家自然科学基金资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy ; General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2447067 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268205]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | SHI Weixing. NEUROBIOLOGY OF PSYCHOSTIMULANT ADDICTION[J]. Chinese Journal of Drug Dependence,2006,15(3):168-172. |
| APA | SHI Weixing.(2006).NEUROBIOLOGY OF PSYCHOSTIMULANT ADDICTION.Chinese Journal of Drug Dependence,15(3),168-172. |
| MLA | SHI Weixing."NEUROBIOLOGY OF PSYCHOSTIMULANT ADDICTION".Chinese Journal of Drug Dependence 15.3(2006):168-172. |
入库方式： OAI收割
来源：上海药物研究所
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