Effects of Urotensin-Ⅱ antagonist on microvascular pathological changes in diabetic retinopathy
文献类型：期刊论文
| 作者 | Ye Xiangyu; Sheng Yaohua; Qiu Changbin; Wang Yulan; Ding Shuangshuang |
| 刊名 | Ophthalmic Research
 |
| 出版日期 | 2006 |
| 卷号 | 24期号:2页码:160-164 |
| 关键词 | Palosuran Urotensin-Ⅱ antagonist diabetic retinopathy Palosuran pericyte basement membrane thickness |
| ISSN号 | 1003-0808 |
| 其他题名 | Urotensin-Ⅱ受体拮抗剂对DR微血管病变的影响 |
| 文献子类 | Article |
| 英文摘要 | Objective Urotensin-Ⅱ is a vasoactive peptide with stronger vasoconstrictive effectiveness. It may be involved in the pathogenesis of diabetic retinopathy. This paper was to assess the effects of Urotensin-Ⅱ antagonist on microvascular pathological changes in diabetic retinopathy （DR）. Methods Animal models of DR were induced by injection of streptozocin in rats. Experimental rats were randomly divided into Sham ＋ Veh （normal control, 11 rats）, DM ＋ Veh （diabetic model without treatment, 7 rats） and DM ＋ 362 （diabetic model with Urotensin-Ⅱ antagonist treatment, 20 rats） groups. Mean body weight and blood glucose levels of rats were recorded every 2 weeks during the experiment period and rats were scarified at the end of 6 months. Left eye of each rat was processed for elastase digest to determine retinal endothelial/pericyte cell ratios and the right eye were used for transmission electron microscopy examination to detect basement membrane thickness. Results Blood glucose level was significantly higher in the DM ＋ Veh group and DM ＋ 362 group than the Sham ＋ Veh group 2 weeks after diabetes was induced, and that of DM ＋ 362 group was considerably lower in comparison with DM ＋ Veh group after 4 weeks. There was no apparent difference in mean body weight between DM ＋ Veh group and DM ＋ 362 group （P 〉 0.05）. Endothelial cell/pericyte ratios and basement membrane thickness were significantly increased in the DM ＋ 362 rats compared with Sham ＋ Veh rats （1.600.01 versus 1.190.01 in E/P ratios, P 〈 0.01 and 106.4018.65 nm versus 83.3614.46 nm in basement membrane thickness, P 〈 0.01） and significantly reduced in comparison with DM ＋ Veh rats （2.100.07 in E/P ratios, P 〈 0.01 and 116.9117.65 nm in basement membrane thickness, P 〈 0.01）. Conclusion Urotensin-Ⅱ antagonist may be useful in prevention from the early pathological changes of DR. |
| WOS研究方向 | Ophthalmology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2337554 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268263]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | Department of Ophthalmology, Xinhua Hospital, Shanghai Jiaotong University, Shanghai 200092, China. |
| 推荐引用方式 GB/T 7714 | Ye Xiangyu,Sheng Yaohua,Qiu Changbin,et al. Effects of Urotensin-Ⅱ antagonist on microvascular pathological changes in diabetic retinopathy[J]. Ophthalmic Research,2006,24(2):160-164. |
| APA | Ye Xiangyu,Sheng Yaohua,Qiu Changbin,Wang Yulan,&Ding Shuangshuang.(2006).Effects of Urotensin-Ⅱ antagonist on microvascular pathological changes in diabetic retinopathy.Ophthalmic Research,24(2),160-164. |
| MLA | Ye Xiangyu,et al."Effects of Urotensin-Ⅱ antagonist on microvascular pathological changes in diabetic retinopathy".Ophthalmic Research 24.2(2006):160-164. |
入库方式： OAI收割
来源：上海药物研究所
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