THE INHIBITORY OF TRIPTOLIDE ON THE EXPRESSION OF COX-2 AND iNOS IN HIPPOCAMPUS INFLAMMATION INDUCED BY LIPOPOLYSACCHARIDE
文献类型：期刊论文
| 作者 | Dai Yuqiao1; Jin Daozhong2; Deng Xiaohua1; Li Jiaming1; Liu Zhengqing1; Luo xuegang1; Lei Deliang1 |
| 刊名 | Chinese Journal of Neuroanatomy
 |
| 出版日期 | 2006 |
| 卷号 | 22期号:5页码:521-524 |
| 关键词 | triptolide lipopolysaccharide cyclooxygenase-2 iuducilde nitric oxide synthase inflammation |
| ISSN号 | 1000-7547 |
| 其他题名 | 雷公藤甲素对LPS诱导的海马炎症过程中COX-2和iNOS表达的影响 |
| 文献子类 | Article |
| 英文摘要 | Immunohistochemistry staining was used to analyse the expression of cyclooxygenase-2 (COX-2) and indncible nitric oxide synthase (iNOS) in hippocampal CA3 regions. In the present study, rats were injected intraperitoneally with triptolide at different doses (10mug·kg~(-1)·d~(-1)，25mug·kg~(-1)·d~(-1)，50mug·kg~(-1)·d~(-1)), prior to the injection of 4mug/4mul lipopolysaccharide (LPS) through hippocampus. The results showed that compared to saline-controlled group, injection of LPS intrahippocampus could induce significant expression of iNOS and COX-2 in hippocampus CA3 regions. However, Triptolide (50 mug·kg~(-1)·d~(-1)) markedly down-regulated LPS-induced COX-2 and iNOS protein expression in hippocampus, and this effect was positively correlated with triptolide doses. Our findings indicated that triptolide can obviously down-regulate LPS-induced COX-2 and iNOS expression in central nervous system. |
| 资助项目 | 高等学校博士学科点专项科研基金资助课题[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2419965 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268264]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China.; 2.Shanghai Institute of Materia Medica, Chinese Acadamy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Dai Yuqiao,Jin Daozhong,Deng Xiaohua,et al. THE INHIBITORY OF TRIPTOLIDE ON THE EXPRESSION OF COX-2 AND iNOS IN HIPPOCAMPUS INFLAMMATION INDUCED BY LIPOPOLYSACCHARIDE[J]. Chinese Journal of Neuroanatomy,2006,22(5):521-524. |
| APA | Dai Yuqiao.,Jin Daozhong.,Deng Xiaohua.,Li Jiaming.,Liu Zhengqing.,...&Lei Deliang.(2006).THE INHIBITORY OF TRIPTOLIDE ON THE EXPRESSION OF COX-2 AND iNOS IN HIPPOCAMPUS INFLAMMATION INDUCED BY LIPOPOLYSACCHARIDE.Chinese Journal of Neuroanatomy,22(5),521-524. |
| MLA | Dai Yuqiao,et al."THE INHIBITORY OF TRIPTOLIDE ON THE EXPRESSION OF COX-2 AND iNOS IN HIPPOCAMPUS INFLAMMATION INDUCED BY LIPOPOLYSACCHARIDE".Chinese Journal of Neuroanatomy 22.5(2006):521-524. |
入库方式： OAI收割
来源：上海药物研究所
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