THE INHIBITORY EFFECTS OF TRIPTOLIDE ON ACTIVATION OF ASTROCYTES AND MICROGLIA IN NEUROINFLAMMATION INDUCED BY LPS
文献类型：期刊论文
| 作者 | Dai Yuqiao1; Jin Daozhong2; Wang Chunxu3; Liu Zhengqing1; Lei Deliang1; Li Minbo1 |
| 刊名 | Chinese Journal of Neuroanatomy
 |
| 出版日期 | 2006 |
| 卷号 | 22期号:6页码:648-652 |
| 关键词 | triptolide neuroinflammation astrocytes microglia |
| ISSN号 | 1000-7547 |
| 其他题名 | 雷公藤甲素对LPS诱导的神经炎症中星形胶质细胞和小胶质细胞激活的抑制作用 |
| 文献子类 | Article |
| 英文摘要 | In the present study, SD rats were administrated intraperitoneally with triptolide at different doses [ 10 ,25 ,50 mug/( kg-d) ] for 5 d, followed by injection of lipopolysaccharide (LPS, 4 mug) into hippocampus for 24 h. The sections were stained by immunohistochemistry ant] histochemistry to examine the expression of glial fibrillary acidic protein( GFAP) in astrocytes and ricinus communis aggluliuin-1 (RCA-1) in microglia of the hippocampus. Our results showed that, compared with saline-control group, injection of LPS induced increased expression of GFAP, and RCA-1 -positive cells were increased in number and size in injected region. Triptolide [50 mug /( kg-d) ] can down-regulated markedly LPS-induced GFAF and RCA-1 expression, which were dose-dependently reduced by triptolide. These findings indicate that triptolide inhibits activation of astrocytes and microglia in LPS-induced neuroinflammation. |
| 资助项目 | 国家教育部博士点基金资助项目[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2638265 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268265]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Department of Anatomy, Bengbu Medical College, Bengbu, Anhui 233003, China.; 2.Shanglmi Institute of Muteria Mediea, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.; 3.Department of Anatomy, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei 430030, China. |
| 推荐引用方式 GB/T 7714 | Dai Yuqiao,Jin Daozhong,Wang Chunxu,et al. THE INHIBITORY EFFECTS OF TRIPTOLIDE ON ACTIVATION OF ASTROCYTES AND MICROGLIA IN NEUROINFLAMMATION INDUCED BY LPS[J]. Chinese Journal of Neuroanatomy,2006,22(6):648-652. |
| APA | Dai Yuqiao,Jin Daozhong,Wang Chunxu,Liu Zhengqing,Lei Deliang,&Li Minbo.(2006).THE INHIBITORY EFFECTS OF TRIPTOLIDE ON ACTIVATION OF ASTROCYTES AND MICROGLIA IN NEUROINFLAMMATION INDUCED BY LPS.Chinese Journal of Neuroanatomy,22(6),648-652. |
| MLA | Dai Yuqiao,et al."THE INHIBITORY EFFECTS OF TRIPTOLIDE ON ACTIVATION OF ASTROCYTES AND MICROGLIA IN NEUROINFLAMMATION INDUCED BY LPS".Chinese Journal of Neuroanatomy 22.6(2006):648-652. |
入库方式： OAI收割
来源：上海药物研究所
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